Ribose 5-phosphate: the key metabolite bridging the metabolisms of nucleotides and amino acids during stringent response in Escherichia coli?

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Ribose 5-phosphate : the key metabolite bridging the metabolisms of nucleotides and amino acids during stringent response in Escherichia coli?. / Grucela, Paulina Katarzyna; Fuhrer, Tobias; Sauer, Uwe; Chao, Yanjie; Zhang, Yong Everett.

In: Microbial Cell, Vol. 10, No. 7, 2023, p. 141-144.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Grucela, PK, Fuhrer, T, Sauer, U, Chao, Y & Zhang, YE 2023, 'Ribose 5-phosphate: the key metabolite bridging the metabolisms of nucleotides and amino acids during stringent response in Escherichia coli?', Microbial Cell, vol. 10, no. 7, pp. 141-144. https://doi.org/10.15698/mic2023.07.799

APA

Grucela, P. K., Fuhrer, T., Sauer, U., Chao, Y., & Zhang, Y. E. (2023). Ribose 5-phosphate: the key metabolite bridging the metabolisms of nucleotides and amino acids during stringent response in Escherichia coli?. Microbial Cell, 10(7), 141-144. https://doi.org/10.15698/mic2023.07.799

Vancouver

Grucela PK, Fuhrer T, Sauer U, Chao Y, Zhang YE. Ribose 5-phosphate: the key metabolite bridging the metabolisms of nucleotides and amino acids during stringent response in Escherichia coli?. Microbial Cell. 2023;10(7):141-144. https://doi.org/10.15698/mic2023.07.799

Author

Grucela, Paulina Katarzyna ; Fuhrer, Tobias ; Sauer, Uwe ; Chao, Yanjie ; Zhang, Yong Everett. / Ribose 5-phosphate : the key metabolite bridging the metabolisms of nucleotides and amino acids during stringent response in Escherichia coli?. In: Microbial Cell. 2023 ; Vol. 10, No. 7. pp. 141-144.

Bibtex

@article{ace93f9b181b44d083e5d0d17f9f1f25,
title = "Ribose 5-phosphate: the key metabolite bridging the metabolisms of nucleotides and amino acids during stringent response in Escherichia coli?",
abstract = "The bacterial stringent response and its effector alarmone guanosine penta- or tetra – phosphates (p)ppGpp are vital for bacterial tolerance and survival of various stresses in environments (including antibiotics) and host cells (virulence). (p)ppGpp does so by binding to its numerous target proteins and reprograming bacterial transcriptome to tune down the synthesis of nucleotides and rRNA/tRNA, and up-regulate amino acid biosynthesis genes. Recent identification of more novel (p)ppGpp direct binding proteins in Escherichia coli and their deep studies have unveiled unprecedented details of how (p)ppGpp coordinates the nucleotide and amino acid metabolic pathways upon stringent response; however, the mechanistic link between nucleotide and amino acid metabolisms remains still incompletely understood. Here we propose the metabolite ribose 5{\textquoteright}-phosphate as the key link between nucleotide and amino acid metabolisms and a working model integrating both the transcriptional and metabolic effects of (p)ppGpp on E. coli physiological adaptation during the stringent response.",
author = "Grucela, {Paulina Katarzyna} and Tobias Fuhrer and Uwe Sauer and Yanjie Chao and Zhang, {Yong Everett}",
year = "2023",
doi = "10.15698/mic2023.07.799",
language = "English",
volume = "10",
pages = "141--144",
journal = "Microbial Cell",
issn = "1475-2859",
publisher = "BioMed Central",
number = "7",

}

RIS

TY - JOUR

T1 - Ribose 5-phosphate

T2 - the key metabolite bridging the metabolisms of nucleotides and amino acids during stringent response in Escherichia coli?

AU - Grucela, Paulina Katarzyna

AU - Fuhrer, Tobias

AU - Sauer, Uwe

AU - Chao, Yanjie

AU - Zhang, Yong Everett

PY - 2023

Y1 - 2023

N2 - The bacterial stringent response and its effector alarmone guanosine penta- or tetra – phosphates (p)ppGpp are vital for bacterial tolerance and survival of various stresses in environments (including antibiotics) and host cells (virulence). (p)ppGpp does so by binding to its numerous target proteins and reprograming bacterial transcriptome to tune down the synthesis of nucleotides and rRNA/tRNA, and up-regulate amino acid biosynthesis genes. Recent identification of more novel (p)ppGpp direct binding proteins in Escherichia coli and their deep studies have unveiled unprecedented details of how (p)ppGpp coordinates the nucleotide and amino acid metabolic pathways upon stringent response; however, the mechanistic link between nucleotide and amino acid metabolisms remains still incompletely understood. Here we propose the metabolite ribose 5’-phosphate as the key link between nucleotide and amino acid metabolisms and a working model integrating both the transcriptional and metabolic effects of (p)ppGpp on E. coli physiological adaptation during the stringent response.

AB - The bacterial stringent response and its effector alarmone guanosine penta- or tetra – phosphates (p)ppGpp are vital for bacterial tolerance and survival of various stresses in environments (including antibiotics) and host cells (virulence). (p)ppGpp does so by binding to its numerous target proteins and reprograming bacterial transcriptome to tune down the synthesis of nucleotides and rRNA/tRNA, and up-regulate amino acid biosynthesis genes. Recent identification of more novel (p)ppGpp direct binding proteins in Escherichia coli and their deep studies have unveiled unprecedented details of how (p)ppGpp coordinates the nucleotide and amino acid metabolic pathways upon stringent response; however, the mechanistic link between nucleotide and amino acid metabolisms remains still incompletely understood. Here we propose the metabolite ribose 5’-phosphate as the key link between nucleotide and amino acid metabolisms and a working model integrating both the transcriptional and metabolic effects of (p)ppGpp on E. coli physiological adaptation during the stringent response.

U2 - 10.15698/mic2023.07.799

DO - 10.15698/mic2023.07.799

M3 - Journal article

C2 - 37395996

VL - 10

SP - 141

EP - 144

JO - Microbial Cell

JF - Microbial Cell

SN - 1475-2859

IS - 7

ER -

ID: 360336000