Søren Tvorup Christensen
Professor
Cell Biology and Physiology
Universitetsparken 13
2100 København Ø
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TGFβ Signaling Increases Net Acid Extrusion, Proliferation and Invasion in Panc-1 Pancreatic Cancer Cells: SMAD4 Dependence and Link to Merlin/NF2 Signaling
Malinda, R. R., Zeeberg, K., Sharku, P. C., Ludwig, M. Q., Pedersen, Lotte Bang, Christensen, Søren Tvorup & Pedersen, Stine Helene Falsig, 2020, In: Frontiers in Oncology. 10, 15 p., 687.Research output: Contribution to journal › Journal article › Research › peer-review
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Patient-specific three-dimensional explant spheroids derived from human nasal airway epithelium: a simple methodological approach for ex vivo studies of primary ciliary dyskinesia
Marthin, J. K., Stevens, E. M., Larsen, Lars Allan, Christensen, Søren Tvorup & Nielsen, Kim G., 23 Mar 2017, In: Cilia. 6, 9 p., 3.Research output: Contribution to journal › Journal article › Research › peer-review
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Primary cilia as dynamic and diverse signalling hubs in development and disease
Mill, P., Christensen, Søren Tvorup & Pedersen, Lotte Bang, 2023, In: Nature Reviews. Genetics. 24, 21 p.Research output: Contribution to journal › Review › Research › peer-review
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Analysis of caveolin in primary cilia
Morthorst, Stine Kjær, Mogensen, J. B., Christensen, Søren Tvorup & Pedersen, Lotte Bang, 2020, Caveolae: Methods and Protocols. Blouin, C. M. (ed.). Humana Press, p. 27-41 (Methods in Molecular Biology, Vol. 2169).Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research
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Regulation of ciliary membrane protein trafficking and signalling by kinesin motor proteins
Morthorst, Stine Kjær, Christensen, Søren Tvorup & Pedersen, Lotte Bang, 2018, In: F E B S Journal. 285, 24, p. 4535-4564Research output: Contribution to journal › Review › Research › peer-review
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Angiomotin isoform 2 promotes binding of PALS1 to KIF13B at primary cilia and regulates ciliary length and signaling
Morthorst, Stine Kjær, Nielsen, C., Farinelli, P., Anvarian, Zeinab, Rasmussen, C. B. R., Serra-Marques, A., Grigoriev, I., Altelaar, M., Fürstenberg, N., Ludwig, A., Akhmanova, A., Christensen, Søren Tvorup & Pedersen, Lotte Bang, 2022, In: Journal of Cell Science. 135, 12, 10 p., jcs259471.Research output: Contribution to journal › Journal article › Research › peer-review
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The intraflagellar transport machinery in ciliary signaling
Mourão, A., Christensen, Søren Tvorup & Lorentzen, E., 2016, In: Current Opinion in Structural Biology. 41, p. 98-108 11 p.Research output: Contribution to journal › Review › Research › peer-review
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The genetic background of hydrocephalus in a population-based cohort: implication of ciliary involvement
Munch, Tina Nørgaard, Hedley, P. L., Hagen, C. M., Baekvad-Hansen, M., Geller, F., Bybjerg-Grauholm, J., Nordentoft, Merete, Borglum, A. D., Werge, Thomas, Melbye, M., Hougaard, D. M., Larsen, Lars Allan, Christensen, Søren Tvorup & Christiansen, M., 2023, In: Brain Communications. 5, 1, 14 p., fcad004.Research output: Contribution to journal › Journal article › Research › peer-review
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CEP128 Localizes to the Subdistal Appendages of the Mother Centriole and Regulates TGF-β/BMP Signaling at the Primary Cilium
Mönnich, M., Borgeskov, L., Breslin, L., Jakobsen, L., Rogowski, M., Doganli, Canan, Schrøder, J. M., Mogensen, J. B., Blinkenkjær, L., Harder, L. M., Lundberg, E., Geimer, S., Christensen, Søren Tvorup, Andersen, J. S., Larsen, Lars Allan & Pedersen, Lotte Bang, 2018, In: Cell Reports. 22, 10, p. 2584-2592 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Expression of the oncogenic, constitutive active Platelet-Derived Growth Factor Receptor alpha D842V mutant induces loss of primary cilia
Nielsen, B. S., Schmid, F., Malinda, R., Christensen, Søren Tvorup & Pedersen, Lotte Bang, 2015, In: Cilia. 4, Suppl. 1, 1 p., P63.Research output: Contribution to journal › Conference abstract in journal › Research › peer-review
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PDGFRβ and oncogenic mutant PDGFRα D842V promote disassembly of primary cilia through a PLCγ- and AURKA-dependent mechanism
Nielsen, B. S., Malinda, R. R., Schmid, F. M., Pedersen, Stine Helene Falsig, Christensen, Søren Tvorup & Pedersen, Lotte Bang, 2015, In: Journal of Cell Science. 128, p. 3543-3549 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Effects of osmotic stress on the activity of MAPKs and PDGFR-beta-mediated signal transduction in NIH-3T3 fibroblasts
Nielsen, M., Christensen, Søren Tvorup & Hoffmann, E. K., 2008, In: American Journal of Physiology: Cell Physiology. 294, 4, p. C1046-55Research output: Contribution to journal › Journal article › Research › peer-review
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In human granulosa cells from small antral follicles, androgen receptor mRNA and androgen levels in follicular fluid correlate with FSH receptor mRNA
Nielsen, M. E., Rasmussen, I. A., Kristensen, S. G., Christensen, Søren Tvorup, Møllgård, Kjeld, Andersen, Elisabeth Anne Wreford, Byskov, A. G. S. & tcg964, tcg964, 2011, In: Molecular Human Reproduction. 17, 1, p. 63-70 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Activation of MAP Kinases upon hypertonic cell shrinkage in NIH3T3 Fibroblasts
Nielsen, M., Christensen, Søren Tvorup & Hoffmann, E. K., 2004, In: Acta Physiologica (Print Edition). A45–A163, p. A108Research output: Contribution to journal › Conference abstract in journal › Research
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Characterization of primary cilia and Hedgehog signaling during development of the human pancreas and in human pancreatic duct cancer cell lines.
Nielsen, S. K., Møllgård, Kjeld, Clement, C. A., Veland, I. R., Awan, A., Yoder, B. K., Novak, Ivana & Christensen, Søren Tvorup, 2008, In: Developmental Dynamics. 237, 8, p. 2039-52 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Cell context-specific expression of primary cilia in the human testis and ciliary coordination of Hedgehog signalling in mouse Leydig cells
Nygaard, M. B., Almstrup, Kristian, Lindbæk, L., Christensen, Søren Tvorup & Svingen, T., 2015, In: Scientific Reports. 5, 14 p., 10364 .Research output: Contribution to journal › Journal article › Research › peer-review
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N-acetylcysteine protects ovarian follicles from ischemia-reperfusion injury in xenotransplanted human ovarian tissue
Olesen, H. Ø., Pors, S. E., Jensen, L. B., Grønning, A. P., Lemser, C. E., Heimbürger, M. T. H. N., Mamsen, L. S., Getreu, N., Christensen, Søren Tvorup, tcg964, tcg964 & Kristensen, S. G., 2021, In: Human Reproduction. 36, 2, p. 429-443 15 p.Research output: Contribution to journal › Journal article › Research › peer-review
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The lissencephaly protein Lis1 is present in motile mammalian cilia and requires outer arm dynein for targeting to Chlamydomonas flagella.
Pedersen, Lotte Bang, Rompolas, P., Christensen, Søren Tvorup, Rosenbaum, J. L. & King, S. M., 2007, In: Journal of Cell Science. 120, Pt 5, p. 858-67 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Assembly of primary cilia.
Pedersen, Lotte Bang, Veland, I. R., Schrøder, J. M. & Christensen, Søren Tvorup, 2008, In: Developmental Dynamics. 237, p. 1993-2006 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Endocytic control of cellular signaling at the primary cilium
Pedersen, Lotte Bang, Mogensen, J. B. & Christensen, Søren Tvorup, 2016, In: Trends in Biochemical Sciences. 41, 9, p. 784-797 14 p.Research output: Contribution to journal › Review › Research › peer-review
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Kroppens indre antenner
Pedersen, Lotte Bang & Christensen, Søren Tvorup, 2007, In: Aktuel Naturvidenskab. 2, p. 10-13Research output: Contribution to journal › Journal article › Communication
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The ciliary cytoskeleton
Pedersen, Lotte Bang, Schrøder, J. M., Satir, P. & Christensen, Søren Tvorup, 2012, In: Comprehensive Physiology. 2, 1, p. 779-803 25 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Cilia and flagella
Pedersen, Lotte Bang, Jurisch-Yaksi, N., Schmid, F. M. & Christensen, Søren Tvorup, 2023, Encyclopedia of Cell Biology, Second Edition. Bradshaw, R. A., Hart, G. W. & Stahl, P. D. (eds.). 2 ed. Oxford: Elsevier, Vol. 3. p. 164-188 25 p.Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
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Regulating intraflagellar transport
Pedersen, Lotte Bang & Christensen, Søren Tvorup, 2012, In: Nature Cell Biology. 14, 9, p. 904-906 3 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Mechanisms of activation of NHE by cell shrinkage and by calyculin A in Ehrlich ascites tumor cells.
Pedersen, Stine Helene Falsig, Varming, C., Christensen, Søren Tvorup & Hoffmann, E. K., 2002, In: Journal of Membrane Biology. 189, 1, p. 67-81 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
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The E3 ubiquitin ligase SMURF1 regulates cell-fate specification and outflow tract septation during mammalian heart development
Rasmussen, K. K., Skat-Rørdam, Josephine, Andersen, P., Warzecha, C. B., Pye, M., Andersen, T. A., Ajbro, K. D., Bendsen, E., Narimatsu, M., Vilhardt, Frederik, Pedersen, Lotte Bang, Wrana, J. L., Anderson, R. H., Møllgård, Kjeld, Christensen, Søren Tvorup & Larsen, Lars Allan, 2018, In: Scientific Reports. 8, 1, 14 p., 9542.Research output: Contribution to journal › Journal article › Research › peer-review
Cell survival and multiplication. The overriding need for signals: from unicellular to multicellular systems
Rasmussen, L., Christensen, Søren Tvorup, Schousboe, P. & Wheatley, D. N., 1996, In: FEMS Microbiology Letters. 137, 2-3, p. 123-8 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
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TSC1 and TSC2 regulate cilia length and canonical Hedgehog signaling via different mechanisms
Rosengren, T., Larsen, L. J., Pedersen, Lotte Bang, Christensen, Søren Tvorup & Møller, L. B., 2018, In: Cellular and Molecular Life Sciences. 75, 14, p. 2663-2680 18 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Peter Satir (1936-2022), cell biology pioneer and mentor
Sale, W. S. & Christensen, Søren Tvorup, 2022, In: Journal of Cell Science. 135, 23Research output: Contribution to journal › Comment/debate › Research
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Evolutionary implications of localization of the signaling scaffold protein Parafusin to both cilia and the nucleus
Satir, B. H., Wyroba, E., Liu, L., Lethan, M., Satir, P. & Christensen, Søren Tvorup, 2015, In: Cell Biology International. 39, 2, p. 136-145 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Structure and function of mammalian cilia
Satir, P. & Christensen, Søren Tvorup, 2008, In: Histochemistry and Cell Biology. 129, 6, p. 687-93 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
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The primary cilium at a glance
Satir, P., Pedersen, Lotte Bang & Christensen, Søren Tvorup, 2010, In: Journal of Cell Science. 123, Pt 4, p. 499-503 4 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Non-motile primary cilia in development of unexpected sensory systems
Satir, P., Guerra, C. F., Schneider, L., Teilmann, S. C., Hoffmann, E. K. & Christensen, Søren Tvorup, 2005, In: The FASEB Journal. Vol. 19 8 (5) Part 2. Suppl., p. A1368-A1369Research output: Contribution to journal › Journal article › Research › peer-review
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Overview of structure and function of mammalian cilia
Satir, P. & Christensen, Søren Tvorup, 2007, In: Annual Review of Physiology. 69, p. 377-400 23 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Cilia and flagella
Schmid, F. M., Christensen, Søren Tvorup & Pedersen, Lotte Bang, 2016, Encyclopedia of cell biology. Bradshaw, R. A. & Stahl, P. D. (eds.). 1 ed. Elsevier, Vol. 2. p. 660-676 17 p.Research output: Chapter in Book/Report/Conference proceeding › Encyclopedia chapter › Research › peer-review
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IFT20 modulates ciliary PDGFRα signaling by regulating the stability of Cbl E3 ubiquitin ligases
Schmid, F. M., Schou, K. B., Vilhelm, M. J., Holm, M. S., Breslin, L., Farinelli, P., Larsen, Lars Allan, Andersen, J. S., Pedersen, Lotte Bang & Christensen, Søren Tvorup, 2018, In: Journal of Cell Biology. 217, 1, p. 151-161 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Directional cell migration and chemotaxis in wound healing response to PDGF-AA are coordinated by the primary cilium in fibroblasts
Schneider, L., Cammer, M., Lehman, J., Nielsen, S. K., Guerra, C. F., Veland, I. R., Stock, C., Hoffmann, E. K., Yoder, B. K., Schwab, A., Satir, P. & Christensen, Søren Tvorup, 2010, In: Cellular Physiology and Biochemistry. 25, 2-3, p. 279-92 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
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The Na+/H+ exchanger NHE1 is required for directional migration stimulated via PDGFR-alpha in the primary cilium
Schneider, L., Stock, C., Dieterich, P., Jensen, B. H., Pedersen, Lotte Bang, Satir, P., Schwab, A., Christensen, Søren Tvorup & Pedersen, Stine Helene Falsig, 2009, In: Journal of Cell Biology. 185, 1, p. 163-76 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Cell shrinkage in NIH3T3-fibroblasts leads to activation of the stress-activated kinases p38, JNK and the transcription factor p53 followed by apoptosis
Schneider, L., Nielsen, M., Christensen, Søren Tvorup & Hoffmann, E. K., 2003, In: Molecular Biology of the Cell. volume 14, p. 162aResearch output: Contribution to journal › Journal article › Research › peer-review
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A mechanism for growth arrest control in the primary cilium based on PDGR-alpha
Schneider, L., Hoffmann, E. K., Satir, P. & Christensen, Søren Tvorup, 2003, In: Molecular Biology of the Cell. p. 323aResearch output: Contribution to journal › Conference abstract in journal › Research
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Tissue Homeostasis is Regulated by the Primary Cilium in Fibroblasts
Schneider, L., Pazour, G., Hoffmann, E. K., Satir, P. & Christensen, Søren Tvorup, 2005, In: Molecular Biology of the Cell. Suppl., p. 648 aResearch output: Contribution to journal › Journal article › Research › peer-review
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H-ras transformation sensitizes volume-activated anion channels and increases migratory activity of NIH3T3 fibroblasts.
Schneider, L., Klausen, T. K., Stock, C., Mally, S., Christensen, Søren Tvorup, Pedersen, Stine Helene Falsig, Hoffmann, E. K. & Schwab, A., 2008, In: Pflügers Archiv: European Journal of Physiology. 455, 6, p. 1055-62 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
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PDGFRaa Signaling Is Regulated through the Primary Cilium in Fibroblasts
Schneider, L., Clement, C. A., Teilmann, S. C., Pazour, G., Hofman, K., Satir, P. & Christensen, Søren Tvorup, 2005, In: Current Biology. 15, 20, p. 1861-1866Research output: Contribution to journal › Journal article › Research › peer-review
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Apoptosis induced by hypertonicity-activation and nuclear translocation of the tumor suppressor p53 in NIH3T3-fibroblasts
Schneider, L. & Christensen, Søren Tvorup, 2004, In: Acta Physiologica (Print Edition). A45–A163, p. A108Research output: Contribution to journal › Conference abstract in journal › Research
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Kinesin-3 motor protein KIF13B localizes to centrosomes and primary cilia and regulates ciliary length and signaling
Schou, K. B., Mogensen, J. B., Aleliunaite, A., Morthorst, Stine Kjær, Veland, I., Christensen, Søren Tvorup & Pedersen, Lotte Bang, 2015, In: Cilia. 4, Suppl. 1, 1 p., O3.Research output: Contribution to journal › Conference abstract in journal › Research › peer-review
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Identification of conserved, centrosome-targeting ASH domains in TRAPPII complex subunits and TRAPPC8
Schou, K. B., Morthorst, Stine Kjær, Christensen, Søren Tvorup & Pedersen, Lotte Bang, 2014, In: Cilia. 3, 6, 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Ins and outs of GPCR signaling in primary cilia
Schou, K. B., Pedersen, Lotte Bang & Christensen, Søren Tvorup, 2015, In: E M B O Reports. 16, 9, p. 1099-1113 15 p.Research output: Contribution to journal › Review › Research › peer-review
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Early-stage apoptosis is associated with DNA-damage-independent ATM phosphorylation and chromatin decondensation in NIH3T3 fibroblasts.
Schou, K. B., Schneider, L., Christensen, Søren Tvorup & Hoffmann, E. K., 2008, In: Cell Biology International. 32, 1, p. 107-13 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
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KIF13B establishes a CAV1-enriched microdomain at the ciliary transition zone to promote Sonic hedgehog signalling.
Schou, K. B., Mogensen, J. B., Morthorst, Stine Kjær, Nielsen, B. S., Aleliunaite, A., Serra-Marques, A., Fürstenberg, N., Saunier, S., Bizet, A. A., Veland, I. R., Akhmanova, A., Christensen, Søren Tvorup & Pedersen, Lotte Bang, 30 Jan 2017, In: Nature Communications. 8, 15 p., 14177.Research output: Contribution to journal › Journal article › Research › peer-review
Compounds stimulating growth and multiplication in ciliates. Do also free-living cells release growth factors?
Schousboe, P., Christensen, Søren Tvorup, Ghiladi, M. & Rasmussen, L., 1992, In: Die Naturwissenschaften. 79, 5, p. 234-5 1 p.Research output: Contribution to journal › Journal article › Research › peer-review
ID: 4693
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Inversin/Nephrocystin-2 is required for fibroblast polarity and directional cell migration
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Identification of conserved, centrosome-targeting ASH domains in TRAPPII complex subunits and TRAPPC8
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Primary cilia and aberrant cell signaling in epithelial ovarian cancer
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