Glucagon secreting alpha cells – physiology and metabolism

Glucagon is an important regulator of glucose homeostasis. During fasting, increased levels of glucagon circulate to promote glucose production from the liver. Glucose is therefore considered a potent inhibitor of glucagon secretion. In diseases such as obesity and diabetes, glucose are no longer able to reduce glucagon levels and it is likely that this contributres to hyperglycaemia and metabolic disease. Despite this, we know very little about the glucagon secreting alpha cell.

Our research aims to expand our basic understanding of alpha cells. We are interested in alpha cell metabolism, how glucagon secretion is regulated, how alpha cells interact with the sorrounding environment and how changes in alpha cell function contribute to the development of diabetes.






Find recent publications at the JGK Lab external homepage.







  • Novo Nordisk foundation Project Grant endocrinology and metabolism (2023-2025) DKK 2M
  • ERC starting grant (2022-2028) EUR 1.659M
  • Novo Nordisk foundation Project Grant endocrinology and metabolism (2022) DKK 1M
  • Sapere Aude: DFF starting grant, Independent Research Fund Denmark (2020-2025) DKK6.3M
  • Novo Nordisk foundation Excellence Emerging Investigator Grant (2019-2024) DKK 9.9M


Name Title Phone E-mail
Alexander Erwin Früh Research Assistant   E-mail
Alexander Hamilton Guest Researcher   E-mail
Dorthe Nielsen Laboratory Technician +4535330260 E-mail
Ganga Deshar Postdoc +4535337868 E-mail
Georgios Katzilieris Petras Postdoc +4535333268 E-mail
Jakob Grunnet Knudsen Assistant Professor +4535324194 E-mail
Renata Ialchina Postdoc +4535332915 E-mail


Assistant Professor
Jakob Grunnet Knudsen
August Krogh Building room 429
Universitetsparken 13
DK-2100 Copenhagen Ø

Phone: +45 35 32 41 94
SoMe: LinkedIn
External homepage


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