Søren Tvorup Christensen
Professor
Cell Biology and Physiology
Universitetsparken 13
2100 København Ø
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Mutation of the planar cell polarity gene VANGL1 in adolescent idiopathic scoliosis
Andersen, M. R., Farooq, M., Rasmussen, K. K., Kjaer, K. W., Simony, A., Christensen, Søren Tvorup & Larsen, Lars Allan, 2017, In: Spine. 42, 12, p. E702–E707 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Cellular signalling by primary cilia in development, organ function and disease
Anvarian, Zeinab, Mykytyn, K., Mukhopadhyay, S., Pedersen, Lotte Bang & Christensen, Søren Tvorup, 2019, In: Nature Reviews Nephrology. 15, p. 199-219Research output: Contribution to journal › Review › Research › peer-review
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Immunoflourescence and mRNA analysis of human embryonic stem cells (hESCs) grown under feeder-free conditions
Awan, A., Oliveri, R. S., Jensen, P. L., Christensen, Søren Tvorup & tcg964, tcg964, 1 Jan 2010, In: Methods in Molecular Biology. 584, p. 195-210 16 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Human RTEL1 associates with Poldip3 to facilitate responses to replication stress and R-loop resolution
Björkman, A., Johansen, S. L., Lin, L., Schertzer, M., Kanellis, D. C., Katsori, A., Christensen, Søren Tvorup, Luo, Y., Andersen, J. S., Elsässer, S. J., Londono-Vallejo, A., Bartek, J. & Schou, K. B., 2020, In: Genes & Development. 34, 15-16, p. 1065-1074 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
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CGRP-dependent signalling pathways involved in mouse models of GTN- cilostazol- and levcromakalim-induced migraine
Christensen, S. L., Rasmussen, R. H., Ernstsen, C., La Cour, S., David, A., Chaker, J., Haanes, K. A., Christensen, Søren Tvorup, Olesen, Jes & Kristensen, D. M., 2021, In: Cephalalgia. 41, 14, p. 1413-1426 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Smooth muscle ATP-sensitive potassium channels mediate migraine-relevant hypersensitivity in mouse models
Christensen, S. L., Rasmussen, Rikke Holm, Cour, S. L., Ernstsen, C., Hansen, Thomas Folkmann, Kogelman, L. J. A., Lauritzen, S. P., Guzaite, G., Styrishave, Bjarne, Janfelt, Christian, Christensen, Søren Tvorup, Aziz, Q., Tinker, A., Jansen-Olesen, I., Olesen, Jes & Kristensen, D. M., 2022, In: Cephalalgia. 42, 2, p. 93-107Research output: Contribution to journal › Journal article › Research › peer-review
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Chapter 10 the primary cilium coordinates signaling pathways in cell cycle control and migration during development and tissue repair
Christensen, Søren Tvorup, Pedersen, Stine Helene Falsig, Satir, P., Veland, I. R. & Schneider, L., 2008, In: Current Topics in Developmental Biology. 85, p. 261-301 40 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Sensory cilia and integration of signal transduction in human health and disease.
Christensen, Søren Tvorup, Pedersen, Lotte Bang, Schneider, L. & Satir, P., 2007, In: Traffic - International Journal of Intracellular Transport. 8, 2, p. 97-109 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Insulin receptor-like proteins in tetrahymena thermophila ciliary membranes
Christensen, Søren Tvorup, Guerra, C. F., Awan, A., Wheatley, D. N. & Satir, P., 2003, In: Curr. Biol.. 13, p. R50-52Research output: Contribution to journal › Journal article › Research › peer-review
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Receptor tyrosine phosphorylation in cilia: a pathway of growth control?
Christensen, Søren Tvorup, Schneider, L., Teilmann, S. C., Awan, A., Guerra, C. F., Hoffmann, E. K. & Satir, P., 2004, In: Molecular Biology of the Cell. vol. 15, p. 359aResearch output: Contribution to journal › Journal article › Research › peer-review
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Evolution of protein kinases: Identification of tyrosine kinases in sensory cilia of tetrahymena
Christensen, Søren Tvorup, Guerra, C. F., Awan, A., Valentin, T., Wheatley, D. N., Gammeltoft, S. & Satir, P., 2003, In: Molecular Biology of the Cell. vol. 14, p. 433aResearch output: Contribution to journal › Journal article › Research › peer-review
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The primary cilium is a sensory organelle that regulates growth control and tissue homeostasis
Christensen, Søren Tvorup, Schneider, L., Clement, C. A., Pazour, G., Hoffmann, E. K. & Satir, P., 2006, In: The FASEB Journal. 20, p. A437Research output: Contribution to journal › Journal article › Research › peer-review
Insulin produces a biphasic response in Tetrahymena thermophila by stimulating cell survival and activating proliferation in two separate concentration intervals
Christensen, Søren Tvorup, Quie, H., Kemp, K. & Rasmussen, L., 1996, In: Cell Biology International. 20, 6, p. 437-44 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Primary cilia and coordination of receptor tyrosine kinase (RTK) and transforming growth factor β (TGF-β) signaling
Christensen, Søren Tvorup, Morthorst, Stine Kjær, Mogensen, J. B. & Pedersen, Lotte Bang, 2017, In: Cold Spring Harbor Perspectives in Biology. 9, 6, 18 p., a028167.Research output: Contribution to journal › Journal article › Research › peer-review
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High expression of the taurine transporter TauT in primary cilia of NIH3T3 fibroblasts
Christensen, Søren Tvorup, Voss, J. W., Teilmann, S. C. & Lambert, Ian Henry, 2005, In: Cell Biology International. 29, 5, p. 347-351Research output: Contribution to journal › Journal article › Research › peer-review
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Primary cilia and coordination of receptor tyrosine kinase (RTK) signaling
Christensen, Søren Tvorup, Clement, C. A., Satir, P. & Pedersen, Lotte Bang, 2012, In: Journal of Pathology. 226, 2, p. 172-184 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
Mechanisms controlling death, survival and proliferation in a model unicellular eukaryote Tetrahymena thermophila
Christensen, Søren Tvorup, Wheatley, D. N., Rasmussen, M. I. & Rasmussen, L., 1995, In: Cell Death and Differentiation. 2, 4, p. 301-8 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Cell signaling. A ciliary signaling switch
Christensen, Søren Tvorup & Ott, C. M., 2007, In: Science. 317, 5836, p. 330-1 1 p.Research output: Contribution to journal › Journal article › Research › peer-review
Cell death, survival and proliferation in Tetrahymena thermophila. Effects of insulin, sodium nitroprusside, 8-Bromo cyclic GMP, NG-methyl-L-arginine and methylene blue
Christensen, Søren Tvorup, Rasmussen, L., Kemp, K. & Quie, H., 1996, In: Cell Biology International. 20, 10, p. 653-66 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
A regulatory light chain of ciliary outer arm dynein in Tetrahymena thermophila
Christensen, Søren Tvorup, Guerra, C., Wada, Y., Valentin, T., Angeletti, R. H., Satir, P. & Hamasaki, T., 2001, In: Journal of Biological Chemistry. 276, 23, p. 20048-54 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Analysis of primary cilia in directional cell migration in fibroblasts
Christensen, Søren Tvorup, Veland, I., Schwab, A., Cammer, M. & Satir, P., 2013, In: Methods in Enzymology. 525, p. 45-58 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
Insulin rescues the unicellular eukaryote Tetrahymena from dying in a complete, synthetic nutrient medium
Christensen, Søren Tvorup, 1993, In: Cell Biology International. 17, 9, p. 833-7 4 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Signaling in unicellular eukaryotes
Christensen, Søren Tvorup, Leick, V. R. & Rasmussen, L., 1997, In: International Review of Cytology. 177, p. 181-253Research output: Contribution to journal › Journal article › Research
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The primary cilium coordinates early cardiogenesis and hedgehog signaling in cardiomyocyte differentiation
Clement, C. A., Kristensen, S. G., Møllgård, Kjeld, Pazour, G. J., Yoder, B. K., Larsen, Lars Allan & Christensen, Søren Tvorup, 2009, In: Journal of Cell Science. 122, Pt 17, p. 3070-82 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
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PDGF-AA Induced Activation of the Mitogenic Erk1/2-Mek1/2 Pathway Localizes to the Primary Cilium and the Ciliary Basal Body in NIH3T3 Fibroblasts
Clement, C. A., Schneider, L., Teilman, S. C., Satir, P. & Christensen, Søren Tvorup, 2005, In: The FASEB Journal. Suppl., p. 650 aResearch output: Contribution to journal › Journal article › Research › peer-review
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TGF-β Signaling Is Associated with Endocytosis at the Pocket Region of the Primary Cilium
Clement, C. A., Ajbro, K. D., Koefoed, K., Vestergaard, M. L., Veland, I. R., Perestrello Ramos H de Jesus, M., Pedersen, Lotte Bang, Benmerah, A., tcg964, tcg964, Larsen, Lars Allan & Christensen, Søren Tvorup, 2013, In: Cell Reports. 3, 6, p. 1806-1814 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Using Nucleofection of siRNA Constructs for Knockdown of Primary Cilia in P19.CL6 Cancer Stem Cell Differentiation into Cardiomyocytes
Clement, C. A., Larsen, Lars Allan & Christensen, Søren Tvorup, 2009, Methods in Cell Biology. Sloboda, R. D. (ed.). Academic Press, Vol. 94. p. 181-197Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research
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PDGFR alpha signaling in the primary cilium regulates NHE1-dependent fibroblast migration via coordinated differential activity of MEK1/2-ERK1/2-p90(RSK) and AKT signaling pathways
Clement, Ditte Lynge, Mally, S., Stock, C., Lethan, M., Satir, P., Schwab, A., Pedersen, Stine Helene Falsig & Christensen, Søren Tvorup, 2013, In: Journal of Cell Science. 126, 4, p. 953-965 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Primary cilia and aberrant cell signaling in epithelial ovarian cancer
Egeberg, D. L., Lethan, M., Manguso, R., Schneider, L., Awan, A., Jørgensen, T. S., Byskov, A. G., Pedersen, Lotte Bang & Christensen, Søren Tvorup, 2012, In: Cilia. 1, 15, 17 p.Research output: Contribution to journal › Journal article › Research › peer-review
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RRP7A links primary microcephaly to dysfunction of ribosome biogenesis, resorption of primary cilia, and neurogenesis
Farooq, M., Lindbæk, L., Krogh, N., Doganli, C., Keller, C., Mönnich, M., Gonçalves, A. B., Sakthivel, S., Mang, Y., Fatima, A., Andersen, V. S., Hussain, M. S., Eiberg, H., Hansen, L., Kjaer, K. W., Gopalakrishnan, J., Pedersen, L. B., Møllgård, K., Nielsen, H., Baig, S. M. & 3 others, , 2020, In: Nature Communications. 11, 16 p., 5816.Research output: Contribution to journal › Journal article › Research › peer-review
Physiological studies on the effect of Ca2+ on the duration of the lag phase of Saccharomyces cerevisiae
Friis, J., Christensen, Søren Tvorup, Szablewski, L., Schousboe, P. & Rasmussen, L., 1994, In: FEMS Microbiology Letters. 123, 1-2, p. 33-6 3 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Cell shrinkage as a signal to apoptosis in NIH 3T3 fibroblasts.
Friis, M. B., Friborg, C. R., Schneider, L., Nielsen, M., Lambert, Ian Henry, Christensen, Søren Tvorup & Hoffmann, E. K., 2005, In: Journal of Physiology. 567, 2, p. 427-43 16 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Comparative Proteome Bioinformatics: Identification of Phosphotyrosine Signaling Proteins in the Unicellular Protozoan Ciliate Tetrahymena
Gammeltoft, S., Christensen, Søren Tvorup, Joachimiak, M., Hill, E., Guerra, C. F. & Satir, P., 2005, In: The FASEB Journal. Suppl., p. 785 aResearch output: Contribution to journal › Journal article › Research › peer-review
Compounds stimulating growth and multiplication in ciliates. Do also free-living cells release growth factors?
Ghiladi, M., Christensen, Søren Tvorup, Schousboe, P. & Rasmussen, L., 1992, In: Die Naturwissenschaften. 79, 5, p. 234-5 1 p.Research output: Contribution to journal › Journal article › Research › peer-review
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CEP78 functions downstream of CEP350 to control biogenesis of primary cilia by negatively regulating CP110 levels
Gonçalves, A. B., Hasselbalch, S. K., Joensen, B. B., Patzke, S., Martens, P., Ohlsen, S. K., Quinodoz, M., Nikopoulos, K., Suleiman, R., Jeppesen, M. P. D., Weiss, C., Christensen, Søren Tvorup, Rivolta, C., Andersen, J. S., Farinelli, P. & Pedersen, Lotte Bang, 2021, In: eLife. 10, 34 p., e63731.Research output: Contribution to journal › Journal article › Research › peer-review
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Comparison of cultured human cardiomyocyte clusters obtained from embryos/fetuses or derived from human embryonic stem cells
Grubb, Søren, Vestergaard, M. L., Andersen, A. S., Rasmussen, K. K., Mamsen, L., Tuckute, G., Grunnet-Lauridsen, K., Møllgård, Kjeld, Ernst, E., Christensen, Søren Tvorup, Callø, Kirstine & tcg964, tcg964, 2019, In: Stem Cells and Development. 28, 9, p. 608-619Research output: Contribution to journal › Journal article › Research › peer-review
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Tetrahymena cilia - not just oars on a boat
Guerra, C. F., Christensen, Søren Tvorup, Awan, A., Bell, A., Jabbour, N., Valentin, T. & Satir, P., 2003, In: Molecular Biology of the Cell. vol. 14, p. 434aResearch output: Contribution to journal › Journal article › Research › peer-review
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Signaling in Tetrahymena Cilia: Evolution of Ciliary Signaling for Mammalian Growth Control Regulation
Guerra, C. F., Bell, A. J., Awan, A., Christensen, Søren Tvorup & Satir, P., 2005, In: The FASEB Journal. Suppl., p. 652 aResearch output: Contribution to journal › Journal article › Research › peer-review
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Effects of osmotic stress on the activity of receptor tyrosine kinases and MAP kinases in NIH3T3-fibtoblasts
Hoffmann, E. K., Nielsen, M. & Christensen, Søren Tvorup, 2004, In: Molecular Biology of the Cell. 15, p. 14aResearch output: Contribution to journal › Journal article › Research › peer-review
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Proteomic analysis of human blastocoel fluid and blastocyst cells
Jensen, P., Beck, H. C., Petersen, J., Hreinsson, J., Wånggren, K., Laursen, S. B., Sørensen, P. D., Christensen, Søren Tvorup & tcg964, tcg964, 2013, In: Stem Cells and Development. 22, 7, p. 1126-1135 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Proteomic analysis of bovine blastocoel fluid and blastocyst cells
Jensen, P. L., Grøndahl, M. L., Beck, H. C., Petersen, J., Stroebech, L., Christensen, Søren Tvorup & tcg964, tcg964, 2014, In: Systems Biology in Reproductive Medicine. 60, 3, p. 127-135 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Editorial: Signaling by primary cilia in development and disease
Kim, S. E., Nechipurenko, I. & Christensen, Søren Tvorup, 2023, In: Frontiers in Cell and Developmental Biology. 11, 3 p., 1186367.Research output: Contribution to journal › Editorial › Research › peer-review
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Human embryonic stem cells in culture possess primary cilia with hedgehog signaling machinery.
Kiprilov, E. N., Awan, A., Desprat, R., Velho, M., Clement, C. A., Byskov, A. G., tcg964, tcg964, Satir, P., Bouhassira, E. E., Christensen, Søren Tvorup & Hirsch, R. E., 2008, In: Journal of Cell Biology. 180, 5, p. 897-904 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Cilia and coordination of signaling networks during heart development
Koefoed, K., Veland, I. R., Pedersen, Lotte Bang, Larsen, Lars Allan & Christensen, Søren Tvorup, 2014, In: Organogenesis. 10, 1, p. 108-125 18 p.Research output: Contribution to journal › Review › Research › peer-review
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Challenges for the sustainability of university-run biobanks
Kongsholm, Nana Cecilie Halmsted, Christensen, Søren Tvorup, Herrmann, Janne Rothmar, Larsen, Lars Allan, Minssen, Timo, Pedersen, Lotte Bang, Rajam, N., Tommerup, Niels, Tupasela, A. M. & Schovsbo, Jens Hemmingsen, 2018, In: Biopreservation and Biobanking. 16, 4, p. 312-321 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
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TGFβ1-induced recruitment of human bone mesenchymal stem cells is mediated by the primary cilium in a SMAD3-dependent manner
Labour, M., Riffault, M., Christensen, Søren Tvorup & Hoey, D. A., 2016, In: Scientific Reports. 6, 13 p., 35542.Research output: Contribution to journal › Journal article › Research › peer-review
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Hot spots of N2O emission move with the seasonally mobile oxic-anoxic interface in drained organic soils
Lee, A. J., Winther, M. N., Priemé, Anders, Blunier, Thomas & Christensen, Søren Tvorup, 1 Dec 2017, In: Soil Biology & Biochemistry. 115, p. 178-186 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Coordination of TGFβ/BMP signaling is associated with the primary cilium
Lindbæk, L., Warzecha, C. B., Koefoed, K., Mogensen, J. B., Schmid, F., Pedersen, Lotte Bang, Larsen, Lars Allan & Christensen, Søren Tvorup, 2015, In: Cilia. 4, Suppl. 1, 1 p., P17.Research output: Contribution to journal › Conference abstract in journal › Research › peer-review
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Glucocorticoids exert context-dependent effects on cells of the joint in vitro
Madsen, S. H., Andreassen, K. V., Christensen, Søren Tvorup, Karsdal, M. A., Sverdrup, F. M., Bay-Jensen, A. & Henriksen, K., 2011, In: Steroids. 76, 13, p. 1474-82 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Characterization of an ex vivo femoral head model assessed by markers of bone and cartilage turnover
Madsen, S. H., Goettrup, A. S., Thomsen, G., Christensen, Søren Tvorup, Schultz, N., Henriksen, K., Bay-Jensen, A. & Karsdal, M. A., 2011, In: Cartilage. 2, 3, p. 265-278 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Inversin/Nephrocystin-2 is required for fibroblast polarity and directional cell migration
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Identification of conserved, centrosome-targeting ASH domains in TRAPPII complex subunits and TRAPPC8
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Primary cilia and aberrant cell signaling in epithelial ovarian cancer
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