Cell Biology and Physiology

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  1. 2020
  2. Published

    Sprifermin (rhFGF18) versus vehicle induces a biphasic process of extracellular matrix remodeling in human knee OA articular cartilage ex vivo

    Reker, D., Siebuhr, A. S., Thudium, C. S., Gantzel, T., Ladel, C., Michaelis, M., Aspberg, A., Berchtold, Martin Werner, Karsdal, M. A., Gigout, A. & Bay-Jensen, A. C., 2020, In: Scientific Reports. 10, 9 p., 6011.

    Research output: Contribution to journal › Journal article › Research › peer-review

  3. Published

    TGFβ Signaling Increases Net Acid Extrusion, Proliferation and Invasion in Panc-1 Pancreatic Cancer Cells: SMAD4 Dependence and Link to Merlin/NF2 Signaling

    Malinda, R. R., Zeeberg, K., Sharku, P. C., Ludwig, M. Q., Pedersen, Lotte Bang, Christensen, Søren Tvorup & Pedersen, Stine Helene Falsig, 2020, In: Frontiers in Oncology. 10, 15 p., 687.

    Research output: Contribution to journal › Journal article › Research › peer-review

  4. Published

    The Acidic Tumor Microenvironment as a Driver of Cancer

    Boedtkjer, E. & Pedersen, Stine Helene Falsig, 2020, In: Annual Review of Physiology. 82, p. 103-126

    Research output: Contribution to journal › Review › Research › peer-review

  5. Published

    The Connexin 43 Regulator Rotigaptide Reduces Cytokine-Induced Cell Death in Human Islets

    Ghiasi, S. M., Hansen, J. B., Christensen, D. P., Tyrberg, B. & Mandrup-Poulsen, Thomas, 2020, In: International Journal of Molecular Sciences (Online). 21, 12, 15 p., 4311.

    Research output: Contribution to journal › Journal article › Research › peer-review

  6. Published

    The Role of Calmodulin in Tumor Cell Migration, Invasiveness, and Metastasis

    Villalobo, A. & Berchtold, Martin Werner, 2020, In: International Journal of Molecular Sciences (Online). 21, 3, 42 p., 765.

    Research output: Contribution to journal › Review › Research › peer-review

  7. Published

    The Vacuolar H+ ATPase α3 Subunit Negatively Regulates Migration and Invasion of Human Pancreatic Ductal Adenocarcinoma Cells

    Flinck, M., Hagelund, S., Gorbatenko, A., Severin, M., Pedraz-Cuesta, E., Novak, Ivana, Stock, C. & Pedersen, Stine Helene Falsig, 2020, In: Cells. 9, 2, 22 p., 465.

    Research output: Contribution to journal › Journal article › Research › peer-review

  8. Published

    The autocrine role of FGF21 in cultured adipocytes

    Justesen, S., Haugegaard, K. V., Hansen, Jacob B., Hansen, Harald S. & Andersen, B., 2020, In: The Biochemical journal. 477, 13, p. 2477-2487 11 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  9. Published

    The impact of calmodulin on the cell cycle analyzed in a novel human cellular genetic system

    Munk, M., Alcalde, J., Lorentzen, Lasse Gøbel, Villalobo, A., Berchtold, Martin Werner & Panina, S., 2020, In: Cell Calcium. 88, 8 p., 102207.

    Research output: Contribution to journal › Journal article › Research › peer-review

  10. Published

    The rapid “teabag” method for high-end purification of membrane proteins

    Hering, J., Missel, Julie Winkel, Zhang, L., Gunnarsson, A., Castaldo, M., Pedersen, Per Amstrup, Ek, M., Gourdon, Pontus Emanuel & Snijder, H. J., 2020, In: Scientific Reports. 10, 11 p., 16167.

    Research output: Contribution to journal › Journal article › Research › peer-review

  11. Published

    Thermotolerance experiments on active and desiccated states of Ramazzottius varieornatus emphasize that tardigrades are sensitive to high temperatures

    Neves, R. C., Hvidepil, L. K. B., Sørensen-Hygum, T. L., Stuart, R. M. & Møbjerg, Nadja, 2020, In: Scientific Reports. 10, 12 p., 94.

    Research output: Contribution to journal › Journal article › Research › peer-review

  12. Published

    Update of P2Y receptor pharmacology: IUPHAR Review 27

    Jacobson, K. A., Delicado, E. G., Gachet, C., Kennedy, C., von Kügelgen, I., Li, B., Miras-Portugal, M. T., Novak, Ivana, Schöneberg, T., Perez-Sen, R., Thor, D., Wu, B., Yang, Z. & Müller, C. E., 2020, In: British Journal of Pharmacology. 177, 11, p. 2413-2433 21 p.

    Research output: Contribution to journal › Review › Research › peer-review

  13. Published

    Volume Regulation in Epithelia

    Larsen, Erik Hviid & Hoffmann, E. K., 2020, Ion Channels and Transporters of Epitheliain Health and Disease. Hamilton, K. L. & Devor, D. C. (eds.). 2 ed. Springer, Vol. 1. p. 395-460 (Physiology in Health and Disease).

    Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

  14. Published

    Why Warburg Works: Lactate Controls Immune Evasion through GPR81

    Jørgensen, Kathrine Lundø, Trauelsen, Mette, Pedersen, Stine Helene Falsig & Schwartz, Thue W., 2020, In: Cell Metabolism. 31, 4, p. 666–668 3 p.

    Research output: Contribution to journal › Letter › Research › peer-review

  15. Published

    Yeast recombinant production of intact human membrane proteins with long intrinsically disordered intracellular regions for structural studies

    Kassem, N., Kassem, M. M., Pedersen, Stine Helene Falsig, Pedersen, Per Amstrup & Kragelund, Birthe Brandt, 2020, In: Biochimica et Biophysica Acta - Biomembranes. 1862, 6, 14 p., 183272.

    Research output: Contribution to journal › Journal article › Research › peer-review

  16. Published

    m6A-dependent biogenesis of circular RNAs in male germ cells

    Tang, C., Xie, Y., Yu, T., Liu, N., Wang, Z., Woolsey, R. J., Tang, Y., Zhang, X., Qin, W., Zhang, Y., Song, G., Zheng, W., Wang, J., Chen, W., Wei, X., Xie, Z., Klukovich, R., Zheng, H., Quilici, D. R. & Yan, W., 2020, In: Cell Research. 30, p. 211-228 18 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  17. 2019
  18. Published

    3D multicellular models to study the regulation and roles of acid-base transporters in breast cancer

    Czaplinska, D., Elingaard-Larsen, L. O., Rolver, M. G., Severin, M. & Pedersen, Stine Helene Falsig, 20 Dec 2019, In: Biochemical Society Transactions. 47, 6, p. 1689-1700 12 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  19. Published

    1,520 reference genomes from cultivated human gut bacteria enable functional microbiome analyses

    Zou, Y., Xue, W., Luo, G., Deng, Z., Qin, P., Guo, R., Sun, H., Xia, Y., Liang, S., Dai, Y., Wan, D., Jiang, R., Su, L., Feng, Q., Jie, Z., Guo, T., Xia, Z., Liu, C., Yu, J., Lin, Y. & 11 others, Tang, S., Huo, G., Xu, X., Hou, Y., Liu, X., Wang, J., Yang, H., Kristiansen, Karsten, Li, J., Jia, H. & Xiao, L., 2019, In: Nature Biotechnology. 37, 2, p. 179-185

    Research output: Contribution to journal › Journal article › Research › peer-review

  20. Published

    A CD146 FACS Protocol Enriches for Luminal Keratin 14/19 Double Positive Human Breast Progenitors

    Ísberg, Ó. G., Kim, Jiyoung, Fridriksdottir, A. J., Morsing, M., Timmermans-Wielenga, V., Rønnov-Jessen, Lone, Petersen, Ole William & Villadsen, René, 2019, In: Scientific Reports. 9, 11 p., 14843.

    Research output: Contribution to journal › Journal article › Research › peer-review

  21. Published

    A CEP104-CSPP1 Complex Is Required for Formation of Primary Cilia Competent in Hedgehog Signaling

    Frikstad, K. M., Molinari, E., Thoresen, M., Ramsbottom, S. A., Hughes, F., Letteboer, S. J. F., Gilani, S., Schink, K. O., Stokke, T., Geimer, S., Pedersen, Lotte Bang, Giles, R. H., Akhmanova, A., Roepman, R., Sayer, J. A. & Patzke, S., 2019, In: Cell Reports. 28, 7, p. 1907-1922, e1-e6

    Research output: Contribution to journal › Journal article › Research › peer-review

  22. Published

    A novel missense variant in IDH3A causes autosomal recessive retinitis pigmentosa

    Peter, V. G., Nikopoulos, K., Quinodoz, M., Granse, L., Farinelli, P., Superti-Furga, A., Andreasson, S. & Rivolta, C., 2019, In: Ophthalmic Genetics. 40, 2, p. 177-181

    Research output: Contribution to journal › Journal article › Research › peer-review

  23. Published

    Annual Meeting of the International Society of Cancer Metabolism (ISCaM): Metabolic Adaptations and Targets in Cancer

    Avnet, S., Baldini, N., Brisson, L., Pedersen, Stine Helene Falsig, Porporato, P. E., Sonveaux, P., Szabadkai, G. & Pastorekova, S., 2019, In: Frontiers in Oncology. 9, 5 p., 1332.

    Research output: Contribution to journal › Review › Research › peer-review

  24. Published

    Assessing Cell Viability and Death in 3D Spheroid Cultures of Cancer Cells

    Rolver, M. G., Elingaard-Larsen, L. O. & Pedersen, Stine Helene Falsig, 2019, In: Journal of Visualized Experiments. 2019, 148, e59714.

    Research output: Contribution to journal › Journal article › Research › peer-review

  25. Published

    Cellular signalling by primary cilia in development, organ function and disease

    Anvarian, Zeinab, Mykytyn, K., Mukhopadhyay, S., Pedersen, Lotte Bang & Christensen, Søren Tvorup, 2019, In: Nature Reviews Nephrology. 15, p. 199-219

    Research output: Contribution to journal › Review › Research › peer-review

  26. Published

    Characterization of Hailey-Hailey Disease-mutants in presence and absence of wild type SPCA1 using Saccharomyces cerevisiae as model organism

    Muncanovic, D., Justesen, M. H., Preisler, Sarah Spruce & Pedersen, Per Amstrup, 2019, In: Scientific Reports. 9, 25 p., 12442.

    Research output: Contribution to journal › Journal article › Research › peer-review

  27. Published

    Comparative myoanatomy of Tardigrada: new insights from the heterotardigrades Actinarctus doryphorus (Tanarctidae) and Echiniscoides sigismundi (Echiniscoididae)

    Persson, D. K., Halberg, Kenneth Veland, Cardoso Neves, R. A., Jørgensen, Aslak, Kristensen, Reinhardt Møbjerg & Møbjerg, Nadja, 2019, In: B M C Evolutionary Biology. 19, 14 p., 206.

    Research output: Contribution to journal › Journal article › Research › peer-review

  28. Published

    Comparative transcriptomics suggest unique molecular adaptations within tardigrade lineages

    Kamilari, M., Jørgensen, Aslak, Schiøtt, M. & Møbjerg, Nadja, 2019, In: B M C Genomics. 20, 19 p., 607.

    Research output: Contribution to journal › Journal article › Research › peer-review

  29. Published

    Comparison of cultured human cardiomyocyte clusters obtained from embryos/fetuses or derived from human embryonic stem cells

    Grubb, Søren, Vestergaard, M. L., Andersen, A. S., Rasmussen, K. K., Mamsen, L., Tuckute, G., Grunnet-Lauridsen, K., Møllgård, Kjeld, Ernst, E., Christensen, Søren Tvorup, Callø, Kirstine & tcg964, tcg964, 2019, In: Stem Cells and Development. 28, 9, p. 608-619

    Research output: Contribution to journal › Journal article › Research › peer-review

  30. Published

    Distribution of platinum between nuclear and cytosolic fractions: can subcellular fractionation be performed quantitatively?

    Dam, C. S., Lambert, Ian Henry, Gammelgaard, Bente & Stürup, Stefan, 2019, In: Journal of Pharmaceutical and Biomedical Analysis. 165, p. 82-89 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  31. Published

    Effects of oxygen-glucose deprivation (OGD) on barrier properties and mRNA transcript levels of selected marker proteins in brain endothelial cells/astrocyte co-cultures

    Tornabene, E., Helms, H. C. C., Pedersen, Stine Helene Falsig & Larsen, Birger Brodin, 2019, In: PLoS ONE. 14, 8, 20 p., e0221103.

    Research output: Contribution to journal › Journal article › Research › peer-review

  32. Published

    Exercise physiology: future opportunities and challenges

    Han, J., Neufer, D. & Pilegaard, Henriette, 2019, In: Pflügers Archiv - European Journal of Physiology. 471, 3, p. 381 1 p.

    Research output: Contribution to journal › Editorial › Research › peer-review

  33. Published

    Extreme stress tolerance in tardigrade: with a focus on modelling cryptobiotic survival

    Sørensen-Hygum, T. L., 2019, Department of Biology, Faculty of Science, University of Copenhagen.

    Research output: Book/Report › Ph.D. thesis › Research

  34. Published

    First report of Loricifera from the North East Pacific Region, with the description of two new species

    Cardoso Neves, R. A., Kristensen, Reinhardt Møbjerg, Rohal, M., Thistle, D. & Sørensen, Martin Vinther, 2019, In: Marine Biodiversity. 49, 3, p. 1151-1168 18 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  35. Published

    HER2 and p95HER2 differentially regulate miRNA expression in MCF-7 breast cancer cells and downregulate MYB proteins through miR-221/222 and miR-503

    Gorbatenko, A., Søkilde, R., Sorensen, E. E., Newie, I., Persson, H., Morancho, B., Arribas, J., Litman, Thomas, Rovira, C. & Pedersen, Stine Helene Falsig, 2019, In: Scientific Reports. 9, 1, p. 1-16 3352.

    Research output: Contribution to journal › Journal article › Research › peer-review

  36. Published

    Human aquaporin-5 facilitates hydrogen peroxide permeation affecting adaption to oxidative stress and cancer cell migration

    Rodrigues, C., Pimpão, C., Mósca, A. F., Coxixo, A. S., Lopes, D., Da Silva, I. V., Pedersen, Per Amstrup, Antunes, F. & Soveral, G., 2019, In: Cancers. 11, 7, 17 p., 932.

    Research output: Contribution to journal › Journal article › Research › peer-review

  37. Published

    Impact of arrhythmogenic calmodulin variants on small conductance Ca2+-activated K+ (SK3) channels

    Saljic, Arnela, Muthukumarasamy, K. M., la Cour, J. M., Boddum, K., Grunnet, Morten, Berchtold, Martin Werner & Jespersen, Thomas, 2019, In: Physiological Reports. 7, 19, 13 p., e14210.

    Research output: Contribution to journal › Journal article › Research › peer-review

  38. Published

    Inclusion of sprints in moderate intensity continuous training leads to muscle oxidative adaptations in trained individuals

    Gunnarsson, T. G. P., Brandt, N., Fiorenza, Matteo, Hostrup, Morten, Pilegaard, Henriette & Bangsbo, Jens, 2019, In: Physiological Reports. 7, 4, 15 p., e13976.

    Research output: Contribution to journal › Journal article › Research › peer-review

  39. Published

    Isolation of cancer stem cells from squamous cell carcinoma

    Fontenete, S. & Perez-Moreno, Mirna, 2019, Skin Stem Cells: Methods and Protocols. Turksen, K. (ed.). 2. ed. ed. Humana Press, p. 407-414 8 p. (Methods in Molecular Biology, Vol. 1879).

    Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

  40. Published

    Kinesins 1 and 3 Cooperate on the Same Vesicle to Transport Exocytotic Carriers

    Serra-Marques, A., Martin, M., Katrukha, E., Grigoriev, I., Liu, Q., Pedersen, Lotte Bang, Kapitein, L. & Akhmanova, A., 2019, In: Biophysical Journal. 116, 3, Suppl. 1, p. 309a 1526-Plat.

    Research output: Contribution to journal › Conference abstract in journal › Research › peer-review

  41. Published

    Lifelong physical activity is associated with promoter hypomethylation of genes involved in metabolism, myogenesis, contractile properties and oxidative stress resistance in aged human skeletal muscle

    Sailani, M. R., Halling, Jens Frey, Møller, H. D., Lee, H., Plomgaard, Peter Stendahl, Pilegaard, Henriette, Snyder, M. P. & Regenberg, Birgitte, 2019, In: Scientific Reports. 9, p. 1-11 3272.

    Research output: Contribution to journal › Journal article › Research › peer-review

  42. Published

    Lymphatic vessels interact dynamically with the hair follicle stem cell niche during skin regeneration in vivo

    Peña-Jimenez, D., Fontenete, S., Megias, D., Fustero-Torre, C., Graña-Castro, O., Castellana, D., Loewe, R. & Perez-Moreno, Mirna, 2019, In: EMBO Journal. 38, 19, 17 p., e101688.

    Research output: Contribution to journal › Journal article › Research › peer-review

  43. Published

    Molecular basis for the binding and selective dephosphorylation of Na+/H+ exchanger 1 by calcineurin

    Hendus-Altenburger, R., Wang, X., Sjøgaard-Frich, Lise Margrethe, Pedraz Cuesta, E., Sheftic, S. R., Bendsøe, A. H., Page, R., Kragelund, Birthe Brandt, Pedersen, Stine Helene Falsig & Peti, W., 2019, In: Nature Communications. 10, 13 p., 3489.

    Research output: Contribution to journal › Journal article › Research › peer-review

  44. Published

    Overexpression of cyclooxygenase-2 in adipocytes reduces fat accumulation in inguinal white adipose tissue and hepatic steatosis in high-fat fed mice

    Danneskiold-Samsøe, Niels Banhos, Sonne, Si Brask, Larsen, J. M., Hansen, Ann Normann, Fjære, E., Isidor, Marie Sophie, Petersen, S., Henningsen, J., Severi, I., Sartini, L., Schobers, Y., Wolf, J., Nockhers, W. A., Wolfrum, C., Cinti, S., Sina, C., Hansen, Jacob B., Madsen, L., Brix, S. & Kristiansen, Karsten, 2019, In: Scientific Reports. 9, 13 p., 8979.

    Research output: Contribution to journal › Journal article › Research › peer-review

  45. Published

    PGC-1α regulates mitochondrial properties beyond biogenesis with aging and exercise training

    Halling, Jens Frey, Jessen, H., Nøhr-Meldgaard, J., Buch, B. T., Christensen, N. M., Gudiksen, Anders, Jørgensen, Stine Ringholm, Neufer, P. D., Prats Gavalda, Clara & Pilegaard, Henriette, 2019, In: American journal of physiology. Endocrinology and metabolism. 317, 3, p. E513-E525

    Research output: Contribution to journal › Journal article › Research › peer-review

  46. Published

    Possible link between FSH and RANKL release from adipocytes in men with impaired gonadal function including Klinefelter syndrome

    Mortensen, L. J., Lorenzen, M., Jørgensen, N., Andersson, A., Nielsen, J. E., Petersen, L. I., Lanske, B., Juul, Anders, Hansen, Jacob B. & Jensen, M. B., 2019, In: Bone. 123, p. 103-114

    Research output: Contribution to journal › Journal article › Research › peer-review

  47. Published

    Profibrotic epithelial phenotype: a central role for MRTF and TAZ

    Bialik, J. F., Ding, M., Speight, P., Dan, Q., Miranda, M. Z., Di Ciano-Oliveira, C., Kofler, M. M., Rotstein, O. D., Pedersen, Stine Helene Falsig, Szászi, K. & Kapus, A., 2019, In: Scientific Reports. 9, p. 1-14 4323.

    Research output: Contribution to journal › Journal article › Research › peer-review

  48. Published

    Proteins with calmodulin-like domains: structures and functional roles

    Villalobo, A., González-Muñoz, M. & Berchtold, Martin Werner, 2019, In: Cellular and Molecular Life Sciences. 76, 12, p. 2299-2328

    Research output: Contribution to journal › Review › Research › peer-review

  49. Published

    Purification of Functional Human TRP Channels Recombinantly Produced in Yeast

    Zhang, L., Wang, Kaituo, Klærke, Dan Arne, Callø, Kirstine, Lowrey, L., Pedersen, Per Amstrup, Gourdon, Pontus Emanuel & Gotfryd, K., 2019, In: Cells. 8, 2, p. 1-20 148.

    Research output: Contribution to journal › Journal article › Research › peer-review

  50. Published

    Redundancy in regulation of lipid accumulation in skeletal muscle during prolonged fasting in obese men

    Høgild, M. L., Gudiksen, Anders, Pilegaard, Henriette, Stødkilde-Jørgensen, H., Pedersen, S. B., Møller, N., Jørgensen, J. O. L. & Jessen, N., 2019, In: Physiological Reports. 7, 21, 15 p., e14285.

    Research output: Contribution to journal › Journal article › Research › peer-review

  51. Published

    Regulation and structural aspects of the human Na+/H+ exchanger NHE1: Roles of the N-terminal region and interactions with lipids

    Vogensen, J., 2019, Department of Biology, Faculty of Science, University of Copenhagen.

    Research output: Book/Report › Ph.D. thesis › Research

  52. Published

    Role of the P2X7 receptor in the pathogenesis of type 2 diabetes and its microvascular complications

    Solini, A. & Novak, Ivana, 2019, In: Current Opinion in Pharmacology. 47, p. 75-81 7 p.

    Research output: Contribution to journal › Review › Research › peer-review

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