Functional Genomics

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  1. 2019
  2. Published

    (p)ppGpp-mediated stress response induced by defects in outer membrane biogenesis and ATP production promotes survival in Escherichia coli

    Roghanian, Mohammad, Semsey, S., Løbner-Olesen, Anders & Jalalvand, F., 2019, In: Scientific Reports. 9, p. 1-11 2934.

    Research output: Contribution to journal › Journal article › Research › peer-review

  3. Published

    Escherichia coli belonging to ST131 rarely transfers blactx-m-15 to fecal Escherichia coli

    Thingholm, K. R., Hertz, F. B., Løbner-Olesen, Anders, Frimodt-Møller, N. & Nielsen, K. L., 2019, In: Infection and Drug Resistance. 12, p. 2429-2435

    Research output: Contribution to journal › Journal article › Research › peer-review

  4. Published

    Schinus terebinthifolia leaf lectin (SteLL) has anti-infective action and modulates the response of Staphylococcus aureus-infected macrophages

    Lima, I. M. D. S. F., Zagmignan, A., Santos, D. M., Maia, H. S., Silva, L. D. S., Cutrim, B. D. S., Vieira, S. L., Filho, C. M. B., de Sousa, E. M., Napoleão, T. H., Krogfelt, K. A., Løbner-Olesen, Anders, Paiva, P. M. G. & da Silva, L. C. N., 2019, In: Scientific Reports. 9, 14 p., 18159.

    Research output: Contribution to journal › Journal article › Research › peer-review

  5. Published

    A Novel Fluorescence-Based Screen for Inhibitors of the Initiation of DNA Replication in Bacteria

    Klitgaard, R. N. & Løbner-Olesen, Anders, 2019, In: Current Drug Discovery Technologies. 16, 3, p. 272-277

    Research output: Contribution to journal › Journal article › Research › peer-review

  6. Published

    A novel type III CRISPR-Cas system in Lactobacilli: Molecular mechanisms and its application potential

    Lin, Jinzhong, 2019, Department of Biology, Faculty of Science, University of Copenhagen.

    Research output: Book/Report › Ph.D. thesis › Research

  7. Published

    A seed motif for target RNA capture enables efficient immune defence by a type III-B CRISPR-Cas system

    Pan, S., Li, Q., Deng, Ling, Jiang, S., Jin, X., Peng, N., Liang, Y., She, Q. & Li, Y., 2019, In: RNA Biology. 16, 9, p. 1166-1178

    Research output: Contribution to journal › Journal article › Research › peer-review

  8. Published

    Antibacterial mechanisms of GN-2 derived peptides and peptoids against Escherichia coli

    Saporito, P., Biljana, M., Løbner-Olesen, Anders & Jenssen, H., 2019, In: Biopolymers. 110, 6, 9 p., e23275.

    Research output: Contribution to journal › Journal article › Research › peer-review

  9. Published

    CRP Interacts Specifically With Sxy to Activate Transcription in Escherichia coli

    Søndberg, E., Sinha, A. K., Gerdes, K. & Semsey, S., 2019, In: Frontiers in Microbiology. 10, 8 p., 2053.

    Research output: Contribution to journal › Journal article › Research › peer-review

  10. Published

    Cmr3 regulates the suppression on cyclic oligoadenylate synthesis by tag complementarity in a Type III-B CRISPR-Cas system

    Guo, T., Zheng, F., Zeng, Z., Yang, Y., Li, Q., She, Q. & Han, W., 2019, In: RNA Biology. 16, 10, p. 1513-1520

    Research output: Contribution to journal › Journal article › Research › peer-review

  11. Published

    Comparative activity of ceftriaxone, ciprofloxacin and gentamicin as a function of bacterial growth rate probed by Escherichia coli chromosome replication in the mouse peritonitis model

    Haugan, M. S., Løbner-Olesen, Anders & Frimodt-Møller, N., 2019, In: Antimicrobial Agents and Chemotherapy. 63, 2, 13 p., e-02133-18.

    Research output: Contribution to journal › Journal article › Research › peer-review

  12. Published

    Comparative genomics for non-O1/O139 Vibrio cholerae isolates recovered from the Yangtze River Estuary versus V. cholerae representative isolates from serogroup O1

    Gong, L., Yu, P., Zheng, H., Gu, W., He, W., Tang, Y., Wang, Y., Dong, Y., Peng, Xu, She, Q., Xie, L. & Chen, L., 2019, In: Molecular Genetics and Genomics. 294, 2, p. 417-430

    Research output: Contribution to journal › Journal article › Research › peer-review

  13. Published

    Comprehensive search for accessory proteins encoded with archaeal and bacterial type III CRISPR-cas gene cassettes reveals 39 new cas gene families

    Shah, S. A., Alkhnbashi, O. S., Behler, J., Han, W., She, Q., Hess, W. R., Garrett, Roger Antony & Backofen, R., 2019, In: RNA Biology. 16, 4, p. 530-542 13 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  14. Published

    Current View of the Mechanisms Controlling the Transcription of the TOL Plasmid Aromatic Degradation Pathways

    Domínguez-Cuevas, P. & Marqués, S., 2019, Aerobic Utilization of Hydrocarbons, Oils, and Lipids. Rojo, F. (ed.). Springer, p. 573-594 (Handbook of Hydrocarbon and Lipid Microbiology).

    Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

  15. Published

    Efflux-Pump Upregulation: From Tolerance to High-level Antibiotic Resistance?

    Frimodt-Møller, Jakob & Løbner-Olesen, Anders, 2019, In: Trends in Microbiology. 27, 4, p. 291-293

    Research output: Contribution to journal › Journal article › Research › peer-review

  16. Published

    Esc2 promotes telomere stability in response to DNA replication stress

    Jørgensen, S. W., Liberti, S. E., Larsen, N. B., Lisby, Michael, Mankouri, H. W. & Hickson, Ian David, 2019, In: Nucleic Acids Research. 47, 9, p. 4597-4611 15 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  17. Published

    Evolution of the bacterial nucleosidase PpnN and its relation to the stringent response

    Bærentsen, R. L., Brodersen, D. E. & ZHANG, YONG, 2019, In: Microbial Cell Factories. 6, 9, p. 450-453

    Research output: Contribution to journal › Journal article › Research › peer-review

  18. Published

    Examination of bacterial growth rate during host infection and its importance for antimicrobial treatment

    Haugan, M. S., 2019, Department of Biology, Faculty of Science, University of Copenhagen.

    Research output: Book/Report › Ph.D. thesis › Research

  19. Published

    Fatty acid starvation activates RelA by depleting lysine precursor pyruvate

    Sinha, A. K., Winther, K. S., Roghanian, Mohammad & Gerdes, K., 2019, In: Molecular Microbiology. 112, 4, p. 1339-1349

    Research output: Contribution to journal › Journal article › Research › peer-review

  20. Published

    Functions of Orc1-2 in the DNA damageresponsive regulation in Sulfolobus islandicus

    Sun, M., 2019, Department of Biology, Faculty of Science, University of Copenhagen.

    Research output: Book/Report › Ph.D. thesis › Research

  21. Published

    Gene Expression Changes with Minor Effects on the Population Average Have Major Effects on the Occurrence of Cells with Extreme Protein Concentrations

    Svenningsen, Mikkel Skjoldan, Semsey, S. & Mitarai, Namiko, 2019, In: mSphere. 4, 1, p. 1-6 e00575-18.

    Research output: Contribution to journal › Journal article › Research › peer-review

  22. Published

    Growth Rate of Escherichia coli During Human Urinary Tract Infection: Implications for Antibiotic Effect

    Haugan, M. S., Hertz, F. B., Charbon, Godefroid, Sahin, B., Løbner-Olesen, Anders & Frimodt-Møller, N., 2019, In: Antibiotics. 8, 3, 12 p., 92.

    Research output: Contribution to journal › Journal article › Research › peer-review

  23. Published

    Guidelines for DNA recombination and repair studies: cellular assays of DNA repair pathways

    Klein, H. L., Bacinskaja, G., Che, J., Cheblal, A., Elango, R., Epshtein, A., Fitzgerald, D. M., Gómez-González, B., Khan, S. R., Kumar, S., Leland, B. A., Marie, L., Mei, Q., Miné-Hattab, J., Piotrowska, A., Polleys, E. J., Putnam, C. D., Radchenko, E. A., Saada, A. A., Sakofsky, C. J. & 28 others, Shim, E. Y., Stracy, M., Xia, J., Yan, Z., Yin, Y., Aguilera, A., Argueso, J. L., Freudenreich, C. H., Gasser, S. M., Gordenin, D. A., Haber, J. E., Ira, G., Jinks-Robertson, S., King, M. C., Kolodner, R. D., Kuzminov, A., Lambert, S. A. E., Lee, S. E., Miller, K. M., Mirkin, S. M., Petes, T. D., Rosenberg, S. M., Rothstein, R., Symington, L. S., Zawadzki, P., Kim, N., Lisby, Michael & Malkova, A., 2019, In: Microbial Cell Factories. 6, 1, p. 1-64

    Research output: Contribution to journal › Review › Research › peer-review

  24. Published

    Inhibition of Type III CRISPR-Cas Immunity by an Archaeal Virus-Encoded Anti-CRISPR Protein

    Bhoobalan, Yuvaraj, Johansen, T. B., Di Cianni, N. & Peng, Xu, 2019, In: Cell. 179, 2, p. 448-458, e1-e11

    Research output: Contribution to journal › Journal article › Research › peer-review

  25. Published

    Intramolecular Interactions Dominate the Autoregulation of Escherichia coli Stringent Factor RelA

    Turnbull, K. J., Dzhygyr, I., Lindemose, Søren, Hauryliuk, V. & Roghanian, Mohammad, 2019, In: Frontiers in Microbiology. 10, 12 p., 1966.

    Research output: Contribution to journal › Journal article › Research › peer-review

  26. Published

    Investigation of the Sulfolobus islandicus III-B Cmr-α CRISPR-Cas system and SMV1 anti-CRISPR activity

    Guo, T., 2019, Department of Biology, Faculty of Science, University of Copenhagen.

    Research output: Book/Report › Ph.D. thesis › Research

  27. Published

    Mating-type switching by homology-directed recombinational repair: a matter of choice

    Thon, Genevieve, Maki, T., Haber, J. E. & Iwasaki, H., 2019, In: Current Genetics. 65, 2, p. 351-362

    Research output: Contribution to journal › Journal article › Research › peer-review

  28. Published

    Molecular evidence for origin, diversification and ancient gene duplication of plant subtilases (SBTs)

    Xu, Y., Wang, S., Li, L., Sahu, S. K., Petersen, Morten, Liu, X., Melkonian, M., Zhang, G. & Liu, Huan, 2019, In: Scientific Reports. 9, 10 p., 12485.

    Research output: Contribution to journal › Journal article › Research › peer-review

  29. Published

    Phylogenomics Provides New Insights into Gains and Losses of Selenoproteins among Archaeplastida

    Liang, H., Wei, T., Xu, Y., Li, L., Sahu, S. K., Wang, H., Li, H., Fu, X., Zhang, G., Melkonian, M., Liu, X., Wang, S. & Liu, Huan, 2019, In: International Journal of Molecular Sciences (Online). 20, 12, 14 p., 3020.

    Research output: Contribution to journal › Journal article › Research › peer-review

  30. Published

    Predicted highly derived class 1 CRISPR-Cas system in Haloarchaea containing diverged Cas5 and Cas7 homologs but no CRISPR array

    Makarova, K. S., Karamycheva, S., Shah, S. A., Vestergaard, G. A., Garrett, Roger Antony & Koonin, E. V., 2019, In: FEMS Microbiology Letters. 366, 7, 5 p., fnz079.

    Research output: Contribution to journal › Journal article › Research › peer-review

  31. Published

    Quantitative sensing and signalling of single-stranded DNA during the DNA damage response

    Bantele, S. C. S., Lisby, Michael & Pfander, B., 2019, In: Nature Communications. 10, p. 1-12 944.

    Research output: Contribution to journal › Journal article › Research › peer-review

  32. Published

    Regulation of BRCA2 by the Protein Phosphatase 2A

    Ambjørn, Sara Marie, 2019, Department of Biology, Faculty of Science, University of Copenhagen.

    Research output: Book/Report › Ph.D. thesis › Research

  33. Published

    Regulation of Ribonucleotide Reductase and Screening for Species-Specific Inhibitors in Fission Yeast

    Løvschal, K. V., 2019, Department of Biology, Faculty of Science, University of Copenhagen.

    Research output: Book/Report › Ph.D. thesis › Research

  34. Published

    Serine-Threonine Kinases Encoded by Split hipA Homologs Inhibit Tryptophanyl-tRNA Synthetase

    Nielsen, S. V., Turnbull, K. J., Roghanian, Mohammad, Bærentsen, R., Semanjski, M., Brodersen, D. E., Macek, B. & Gerdes, K., 2019, In: mBio. 10, 3, 16 p., e-01138-19.

    Research output: Contribution to journal › Journal article › Research › peer-review

  35. Published

    Stable maintenance of the rudivirus SIRV3 in a carrier state in Sulfolobus islandicus despite activation of the CRISPR-Cas immune response by a second virus SMV1

    Papathanasiou, P., Erdmann, S., Leon-Sobrino, C., Sharma, K., Urlaub, H., Garrett, Roger Antony & Peng, Xu, 2019, In: RNA Biology. 16, 4, p. 557-565

    Research output: Contribution to journal › Journal article › Research › peer-review

  36. Published

    Structure of Csx1-cOA4 complex reveals the basis of RNA decay in Type III-B CRISPR-Cas

    Molina, R., Stella, S., Feng, M., Sofos, N., Jauniskis, V., Pozdnyakova, I., López-Méndez, B., She, Q. & Montoya, Guillermo, 2019, In: Nature Communications. 10, 14 p., 4302.

    Research output: Contribution to journal › Journal article › Research › peer-review

  37. Published

    Structure-Activity Study of an All-D Antimicrobial Octapeptide D2D

    Lone, A., Thomsen, T. T., Nielsen, J. E., Thulstrup, Peter Waaben, Klitgaard, R. N., Løbner-Olesen, Anders, Lund, R., Jenssen, H. & Hansen, Paul Robert, 2019, In: Molecules. 24, 24, 17 p., 4571.

    Research output: Contribution to journal › Journal article › Research › peer-review

  38. Published

    Sulfolobus and SIRV2: An Enduring Love Story

    Bhoobalan, Yuvaraj, 2019, Department of Biology, Faculty of Science, University of Copenhagen.

    Research output: Book/Report › Ph.D. thesis › Research

  39. Published

    Synthesis of Shld Derivatives, Their Binding to the Destabilizing Domain, and Influence on Protein Accumulation in Transgenic Plants

    Jørgensen, F. P., Madsen, D., Meldal, Morten Peter, Olsen, J. V., Petersen, Morten, Granhøj, J. & Bols, Mikael, 2019, In: Journal of Medicinal Chemistry. 62, 10, p. 5191-5216 26 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  40. Published

    The E. coli HicB Antitoxin Contains a Structurally Stable Helix-Turn-Helix DNA Binding Domain

    Manav, M. C., Turnbull, K. J., Jurėnas, D., Garcia-Pino, A., Gerdes, K. & Brodersen, D. E., 2019, In: Structure. 27, 11, p. 1675-1685, e1-e3

    Research output: Contribution to journal › Journal article › Research › peer-review

  41. Published

    The Draft Genome of Hariotina reticulata (Sphaeropleales, Chlorophyta) Provides Insight into the Evolution of Scenedesmaceae

    Xu, Y., Li, L., Liang, H., Melkonian, B., Lorenz, M., Friedl, T., Petersen, Morten, Liu, Huan, Melkonian, M. & Wang, S., 2019, In: Protist. 170, 6, 6 p., 125684.

    Research output: Contribution to journal › Journal article › Research › peer-review

  42. Published

    The Draft Genome of the Small, Spineless Green Alga Desmodesmus costato-granulatus (Sphaeropleales, Chlorophyta)

    Wang, S., Li, L., Xu, Y., Melkonian, B., Lorenz, M., Friedl, T., Petersen, Morten, Sahu, S. K., Melkonian, M. & Liu, Huan, 2019, In: Protist. 170, 6, 5 p., 125697.

    Research output: Contribution to journal › Journal article › Research › peer-review

  43. Published

    The FANCM family Mph1 helicase localizes to the mitochondria and contributes to mtDNA stability

    Bernal, M., Yang, X., Lisby, Michael & Mazón, G., 2019, In: DNA Repair. 82, 11 p., 102684.

    Research output: Contribution to journal › Journal article › Research › peer-review

  44. Published

    The PCNA interaction motifs revisited: thinking outside the PIP-box

    Prestel, Andreas, Wichmann, N., Martins, J. M., Marabini, R., Kassem, N., Broendum, S. S., Otterlei, M., Nielsen, Olaf, Willemoës, Martin, Ploug, Michael, Boomsma, Wouter & Kragelund, Birthe Brandt, 2019, In: Cellular and Molecular Life Sciences. 76, 24, p. 4923-4943

    Research output: Contribution to journal › Journal article › Research › peer-review

  45. Published

    The RES domain toxins of RES-Xre toxin-antitoxin modules induce cell stasis by degrading NAD+

    Skjerning, R. B., Senissar, M., Winther, K. S., Gerdes, K. & Brodersen, D. E., 2019, In: Molecular Microbiology. 111, 1, p. 221-236

    Research output: Contribution to journal › Journal article › Research › peer-review

  46. Published

    Tolerance of Sulfolobus SMV1 virus to the immunity of I-A and III-B CRISPR-Cas systems in Sulfolobus islandicus

    Guo, T., Han, W. & She, Q., 2019, In: RNA Biology. 16, 4, p. 549-556 8 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  47. Published

    Toxin-antitoxin operon kacAT of Klebsiella pneumoniae is regulated by conditional cooperativity via a W-shaped KacA-KacT complex

    Qian, H., Yu, H., Li, P., Zhu, E., Yao, Q., Tai, C., Deng, Z., Gerdes, K., He, X., Gan, J. & Ou, H., 2019, In: Nucleic Acids Research. 47, 14, p. 7690-7702

    Research output: Contribution to journal › Journal article › Research › peer-review

  48. Published

    Comprehensive profiling of the fission yeast transcription start site activity during stress and media response

    Thodberg, Malte, Thieffry, A., Lange, Jette Bornholdt, Boyd, M., Holmberg, Christian, Azad, A., Workman, C. T., Chen, Y., Ekwall, K., Nielsen, Olaf & Sandelin, Albin Gustav, 28 Feb 2019, In: Nucleic Acids Research. 47, 4, p. 1671-1691 21 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  49. Published

    Birth and Resuscitation of (p)ppGpp Induced Antibiotic Tolerant Persister Cells

    Svenningsen, Mikkel Skjoldan, Veress, A., Harms, A., Mitarai, Namiko & Semsey, S., 15 Apr 2019, In: Scientific Reports. 9, 13 p., 6056.

    Research output: Contribution to journal › Journal article › Research › peer-review

  50. Published

    Development and Psychometric Evaluation of an Item Bank for Computerized Adaptive Testing of the EORTC Insomnia Dimension in Cancer Patients (EORTC CAT-SL)

    Dirven, L., Petersen, Morten, Aaronson, N. K., Chie, W., Conroy, T., Costantini, A., Hammerlid, E., Velikova, G., Verdonck-de Leeuw, I. M., Young, T. & Grønvold, Mogens, 6 Dec 2019, In: Applied Research in Quality of Life. 18 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

  51. 2020
  52. Published

    A CRISPR-associated factor Csa3a regulates DNA damage repair in Crenarchaeon Sulfolobus islandicus

    Liu, Z., Sun, M., Liu, J., Liu, T., Ye, Q., Li, Y. & Peng, N., 2020, In: Nucleic Acids Research. 48, 17, p. 9681-9693 13 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

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