A draft genome of the medicinal plant Cremastra appendiculata (D. Don) provides insights into the colchicine biosynthetic pathway

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

A draft genome of the medicinal plant Cremastra appendiculata (D. Don) provides insights into the colchicine biosynthetic pathway. / Wang, Jing; Xie, Jingjing; Chen, Haixia; Qiu, Xia; Cui, Hai; Liu, Yijiang; Sahu, Sunil Kumar; Fang, Dongming; Li, Tengyan; Wang, Mei; Chen, Yewen; Liu, Huan; Zhang, Jianyong; Wang, Binbin.

In: Communications Biology , Vol. 5, 1294, 2022.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Wang, J, Xie, J, Chen, H, Qiu, X, Cui, H, Liu, Y, Sahu, SK, Fang, D, Li, T, Wang, M, Chen, Y, Liu, H, Zhang, J & Wang, B 2022, 'A draft genome of the medicinal plant Cremastra appendiculata (D. Don) provides insights into the colchicine biosynthetic pathway', Communications Biology , vol. 5, 1294. https://doi.org/10.1038/s42003-022-04229-4

APA

Wang, J., Xie, J., Chen, H., Qiu, X., Cui, H., Liu, Y., Sahu, S. K., Fang, D., Li, T., Wang, M., Chen, Y., Liu, H., Zhang, J., & Wang, B. (2022). A draft genome of the medicinal plant Cremastra appendiculata (D. Don) provides insights into the colchicine biosynthetic pathway. Communications Biology , 5, [1294]. https://doi.org/10.1038/s42003-022-04229-4

Vancouver

Wang J, Xie J, Chen H, Qiu X, Cui H, Liu Y et al. A draft genome of the medicinal plant Cremastra appendiculata (D. Don) provides insights into the colchicine biosynthetic pathway. Communications Biology . 2022;5. 1294. https://doi.org/10.1038/s42003-022-04229-4

Author

Wang, Jing ; Xie, Jingjing ; Chen, Haixia ; Qiu, Xia ; Cui, Hai ; Liu, Yijiang ; Sahu, Sunil Kumar ; Fang, Dongming ; Li, Tengyan ; Wang, Mei ; Chen, Yewen ; Liu, Huan ; Zhang, Jianyong ; Wang, Binbin. / A draft genome of the medicinal plant Cremastra appendiculata (D. Don) provides insights into the colchicine biosynthetic pathway. In: Communications Biology . 2022 ; Vol. 5.

Bibtex

@article{a31acbec6c50400086fb482a4e8c473c,
title = "A draft genome of the medicinal plant Cremastra appendiculata (D. Don) provides insights into the colchicine biosynthetic pathway",
abstract = "A draft genome assembly of Cremastra appendiculata (D. Don) Makino, a traditional Chinese medicine plant, identified genes responsible for plant colchicine biosynthesis.Cremastra appendiculata (D. Don) Makino is a rare terrestrial orchid with a high market value as an ornamental and Chinese traditional medicinal herb with a wide range of pharmacological properties. The pseudobulbs of C. appendiculata are one of the primary sources of the famous traditional Chinese medicine {"}Shancigu{"}, which has been clinically used for treating many diseases, especially, as the main component to treat gout. The lack of genetic research and genome data restricts the modern development and clinical use of C. appendiculata. Here, we report a 2.3 Gb chromosome-level genome of C. appendiculata. We identify a series of candidates of 35 candidate genes responsible for colchicine biosynthesis, among which O-methyltransferase (OMT) gene exhibits an important role in colchicine biosynthesis. Co-expression analysis reveal purple and green-yellow module have close relationships with pseudobulb parts and comprise most of the colchicine pathway genes. Overall, our genome data and the candidate genes reported here set the foundation to decipher the colchicine biosynthesis pathways in medicinal plants.",
keywords = "PHENYLALANINE AMMONIA-LYASE, GENE FAMILY, ALKALOIDS, SEQUENCE, DATABASE, TOOL, IDENTIFICATION, PROGRAM, CLASSIFICATION, EXPRESSION",
author = "Jing Wang and Jingjing Xie and Haixia Chen and Xia Qiu and Hai Cui and Yijiang Liu and Sahu, {Sunil Kumar} and Dongming Fang and Tengyan Li and Mei Wang and Yewen Chen and Huan Liu and Jianyong Zhang and Binbin Wang",
year = "2022",
doi = "10.1038/s42003-022-04229-4",
language = "English",
volume = "5",
journal = "Communications Biology",
issn = "2399-3642",
publisher = "nature publishing group",

}

RIS

TY - JOUR

T1 - A draft genome of the medicinal plant Cremastra appendiculata (D. Don) provides insights into the colchicine biosynthetic pathway

AU - Wang, Jing

AU - Xie, Jingjing

AU - Chen, Haixia

AU - Qiu, Xia

AU - Cui, Hai

AU - Liu, Yijiang

AU - Sahu, Sunil Kumar

AU - Fang, Dongming

AU - Li, Tengyan

AU - Wang, Mei

AU - Chen, Yewen

AU - Liu, Huan

AU - Zhang, Jianyong

AU - Wang, Binbin

PY - 2022

Y1 - 2022

N2 - A draft genome assembly of Cremastra appendiculata (D. Don) Makino, a traditional Chinese medicine plant, identified genes responsible for plant colchicine biosynthesis.Cremastra appendiculata (D. Don) Makino is a rare terrestrial orchid with a high market value as an ornamental and Chinese traditional medicinal herb with a wide range of pharmacological properties. The pseudobulbs of C. appendiculata are one of the primary sources of the famous traditional Chinese medicine "Shancigu", which has been clinically used for treating many diseases, especially, as the main component to treat gout. The lack of genetic research and genome data restricts the modern development and clinical use of C. appendiculata. Here, we report a 2.3 Gb chromosome-level genome of C. appendiculata. We identify a series of candidates of 35 candidate genes responsible for colchicine biosynthesis, among which O-methyltransferase (OMT) gene exhibits an important role in colchicine biosynthesis. Co-expression analysis reveal purple and green-yellow module have close relationships with pseudobulb parts and comprise most of the colchicine pathway genes. Overall, our genome data and the candidate genes reported here set the foundation to decipher the colchicine biosynthesis pathways in medicinal plants.

AB - A draft genome assembly of Cremastra appendiculata (D. Don) Makino, a traditional Chinese medicine plant, identified genes responsible for plant colchicine biosynthesis.Cremastra appendiculata (D. Don) Makino is a rare terrestrial orchid with a high market value as an ornamental and Chinese traditional medicinal herb with a wide range of pharmacological properties. The pseudobulbs of C. appendiculata are one of the primary sources of the famous traditional Chinese medicine "Shancigu", which has been clinically used for treating many diseases, especially, as the main component to treat gout. The lack of genetic research and genome data restricts the modern development and clinical use of C. appendiculata. Here, we report a 2.3 Gb chromosome-level genome of C. appendiculata. We identify a series of candidates of 35 candidate genes responsible for colchicine biosynthesis, among which O-methyltransferase (OMT) gene exhibits an important role in colchicine biosynthesis. Co-expression analysis reveal purple and green-yellow module have close relationships with pseudobulb parts and comprise most of the colchicine pathway genes. Overall, our genome data and the candidate genes reported here set the foundation to decipher the colchicine biosynthesis pathways in medicinal plants.

KW - PHENYLALANINE AMMONIA-LYASE

KW - GENE FAMILY

KW - ALKALOIDS

KW - SEQUENCE

KW - DATABASE

KW - TOOL

KW - IDENTIFICATION

KW - PROGRAM

KW - CLASSIFICATION

KW - EXPRESSION

U2 - 10.1038/s42003-022-04229-4

DO - 10.1038/s42003-022-04229-4

M3 - Journal article

C2 - 36434059

VL - 5

JO - Communications Biology

JF - Communications Biology

SN - 2399-3642

M1 - 1294

ER -

ID: 329200400