A draft genome of the medicinal plant Cremastra appendiculata (D. Don) provides insights into the colchicine biosynthetic pathway
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A draft genome assembly of Cremastra appendiculata (D. Don) Makino, a traditional Chinese medicine plant, identified genes responsible for plant colchicine biosynthesis.
Cremastra appendiculata (D. Don) Makino is a rare terrestrial orchid with a high market value as an ornamental and Chinese traditional medicinal herb with a wide range of pharmacological properties. The pseudobulbs of C. appendiculata are one of the primary sources of the famous traditional Chinese medicine "Shancigu", which has been clinically used for treating many diseases, especially, as the main component to treat gout. The lack of genetic research and genome data restricts the modern development and clinical use of C. appendiculata. Here, we report a 2.3 Gb chromosome-level genome of C. appendiculata. We identify a series of candidates of 35 candidate genes responsible for colchicine biosynthesis, among which O-methyltransferase (OMT) gene exhibits an important role in colchicine biosynthesis. Co-expression analysis reveal purple and green-yellow module have close relationships with pseudobulb parts and comprise most of the colchicine pathway genes. Overall, our genome data and the candidate genes reported here set the foundation to decipher the colchicine biosynthesis pathways in medicinal plants.
Original language | English |
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Article number | 1294 |
Journal | Communications Biology |
Volume | 5 |
Number of pages | 12 |
ISSN | 2399-3642 |
DOIs | |
Publication status | Published - 2022 |
- PHENYLALANINE AMMONIA-LYASE, GENE FAMILY, ALKALOIDS, SEQUENCE, DATABASE, TOOL, IDENTIFICATION, PROGRAM, CLASSIFICATION, EXPRESSION
Research areas
ID: 329200400