The sxa2-dependent inactivation of the P-factor mating pheromone in the fission yeast Schizosaccharomyces pombe
Research output: Contribution to journal › Journal article › Research › peer-review
Haploid cells of the fission yeast Schizosaccharomyces pombe exist in one of two mating types, referred to as M and P. Conjugation occurs between cells of opposite mating type and is controlled by the reciprocal action of diffusible pheromones. Loss of function of the sxa2 gene in M cells causes hypersensitivity to the P-factor mating pheromone and a reduction in mating efficiency. Here we demonstrate the secretion of an sxa2-dependent carboxypeptidase that inactivates P-factor by removal of the C-terminal leucine residue.
Original language | English |
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Journal | Molecular Microbiology |
Volume | 20 |
Issue number | 1 |
Pages (from-to) | 35-42 |
Number of pages | 8 |
ISSN | 0950-382X |
Publication status | Published - 1 Apr 1996 |
- Carboxypeptidases, Gene Expression Regulation, Fungal, Genes, Fungal, Genes, Mating Type, Fungal, Hydrogen-Ion Concentration, Pheromones, Schizosaccharomyces, Schizosaccharomyces pombe Proteins, Temperature, Transcription Factors
Research areas
ID: 33577134