In situ quantification of local O2 concentration in 3D bioprinted constructs using luminescent nanoparticles
Research output: Chapter in Book/Report/Conference proceeding › Conference abstract in proceedings › Research › peer-review
One major limitation of tissue engineering approaches is the insufficient supply of the cells with oxygen due to a lack of a functional vascular system ex vivo. In complex 3D culture systems, such as bioprinted constructs with clinically relevant dimensions (Kilian D. MRS Bull. 2017; 42: 582-592), the local O 2 concentration depends on the macroporosity of the hydrogel scaffold as well as on the permeability of the hydrogel material (bioink) which oxygen has to pass through via diffusion. For better understanding new tools are needed to monitor in real time oxygen distribution dynamics within bioprinted constructs. We propose utilisation of cytocompatible O 2 sensitive luminescent nanoparticles (NP) for this purpose.
Original language | English |
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Title of host publication | Society for Biomaterials Annual Meeting and Exposition 2019 : The Pinnacle of Biomaterials Innovation and Excellence - Transactions of the 42nd Annual Meeting |
Number of pages | 1 |
Publisher | Society for Biomaterials |
Publication date | 2019 |
Pages | 135 |
ISBN (Electronic) | 978-1-5108-8390-1 |
Publication status | Published - 2019 |
Event | 42nd Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence - Seattle, United States Duration: 3 Apr 2019 → 6 Apr 2019 |
Conference
Conference | 42nd Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence |
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Land | United States |
By | Seattle |
Periode | 03/04/2019 → 06/04/2019 |
Series | Transactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium |
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Volume | 40 |
ISSN | 1526-7547 |
ID: 225759753