A single-cell atlas of West African lungfish respiratory system reveals evolutionary adaptations to terrestrialization
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A single-cell atlas of West African lungfish respiratory system reveals evolutionary adaptations to terrestrialization. / Zhang, Ruihua; Liu, Qun; Pan, Shanshan; Zhang, Yingying; Qin, Yating; Du, Xiao; Yuan, Zengbao; Lu, Yongrui; Song, Yue; Zhang, Mengqi; Zhang, Nannan; Ma, Jie; Zhang, Zhe; Jia, Xiaodong; Wang, Kun; He, Shunping; Liu, Shanshan; Ni, Ming; Liu, Xin; Xu, Xun; Yang, Huanming; Wang, Jian; Seim, Inge; Fan, Guangyi.
In: Nature Communications, Vol. 14, No. 1, 5630, 2023.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - A single-cell atlas of West African lungfish respiratory system reveals evolutionary adaptations to terrestrialization
AU - Zhang, Ruihua
AU - Liu, Qun
AU - Pan, Shanshan
AU - Zhang, Yingying
AU - Qin, Yating
AU - Du, Xiao
AU - Yuan, Zengbao
AU - Lu, Yongrui
AU - Song, Yue
AU - Zhang, Mengqi
AU - Zhang, Nannan
AU - Ma, Jie
AU - Zhang, Zhe
AU - Jia, Xiaodong
AU - Wang, Kun
AU - He, Shunping
AU - Liu, Shanshan
AU - Ni, Ming
AU - Liu, Xin
AU - Xu, Xun
AU - Yang, Huanming
AU - Wang, Jian
AU - Seim, Inge
AU - Fan, Guangyi
N1 - Publisher Copyright: © 2023, Springer Nature Limited.
PY - 2023
Y1 - 2023
N2 - The six species of lungfish possess both lungs and gills and are the closest extant relatives of tetrapods. Here, we report a single-cell transcriptome atlas of the West African lungfish (Protopterus annectens). This species manifests the most extreme form of terrestrialization, a life history strategy to survive dry periods that can last for years, characterized by dormancy and reversible adaptive changes of the gills and lungs. Our atlas highlights the cell type diversity of the West African lungfish, including gene expression consistent with phenotype changes of terrestrialization. Comparison with terrestrial tetrapods and ray-finned fishes reveals broad homology between the swim bladder and lung cell types as well as shared and idiosyncratic changes of the external gills of the West African lungfish and the internal gills of Atlantic salmon. The single-cell atlas presented here provides a valuable resource for further exploration of the respiratory system evolution in vertebrates and the diversity of lungfish terrestrialization.
AB - The six species of lungfish possess both lungs and gills and are the closest extant relatives of tetrapods. Here, we report a single-cell transcriptome atlas of the West African lungfish (Protopterus annectens). This species manifests the most extreme form of terrestrialization, a life history strategy to survive dry periods that can last for years, characterized by dormancy and reversible adaptive changes of the gills and lungs. Our atlas highlights the cell type diversity of the West African lungfish, including gene expression consistent with phenotype changes of terrestrialization. Comparison with terrestrial tetrapods and ray-finned fishes reveals broad homology between the swim bladder and lung cell types as well as shared and idiosyncratic changes of the external gills of the West African lungfish and the internal gills of Atlantic salmon. The single-cell atlas presented here provides a valuable resource for further exploration of the respiratory system evolution in vertebrates and the diversity of lungfish terrestrialization.
U2 - 10.1038/s41467-023-41309-3
DO - 10.1038/s41467-023-41309-3
M3 - Journal article
C2 - 37699889
AN - SCOPUS:85170680482
VL - 14
JO - Nature Communications
JF - Nature Communications
SN - 2041-1723
IS - 1
M1 - 5630
ER -
ID: 367901497