Translational frontiers: insight from lymphatics in skin regeneration
Research output: Contribution to journal › Review › Research › peer-review
Standard
Translational frontiers : insight from lymphatics in skin regeneration. / Jiang, Yujia; Perez-Moreno, Mirna.
In: Frontiers in Physiology, Vol. 15, 1347558, 2024.Research output: Contribution to journal › Review › Research › peer-review
Harvard
APA
Vancouver
Author
Bibtex
}
RIS
TY - JOUR
T1 - Translational frontiers
T2 - insight from lymphatics in skin regeneration
AU - Jiang, Yujia
AU - Perez-Moreno, Mirna
N1 - Publisher Copyright: Copyright © 2024 Jiang and Perez-Moreno.
PY - 2024
Y1 - 2024
N2 - The remarkable regenerative ability of the skin, governed by complex molecular mechanisms, offers profound insights into the skin repair processes and the pathogenesis of various dermatological conditions. This understanding, derived from studies in human skin and various model systems, has not only deepened our knowledge of skin regeneration but also facilitated the development of skin substitutes in clinical practice. Recent research highlights the crucial role of lymphatic vessels in skin regeneration. Traditionally associated with fluid dynamics and immune modulation, these vessels are now recognized for interacting with skin stem cells and coordinating regeneration. This Mini Review provides an overview of recent advancements in basic and translational research related to skin regeneration, focusing on the dynamic interplay between lymphatic vessels and skin biology. Key highlights include the critical role of stem cell-lymphatic vessel crosstalk in orchestrating skin regeneration, emerging translational approaches, and their implications for skin diseases. Additionally, the review identifies research gaps and proposes potential future directions, underscoring the significance of this rapidly evolving research arena.
AB - The remarkable regenerative ability of the skin, governed by complex molecular mechanisms, offers profound insights into the skin repair processes and the pathogenesis of various dermatological conditions. This understanding, derived from studies in human skin and various model systems, has not only deepened our knowledge of skin regeneration but also facilitated the development of skin substitutes in clinical practice. Recent research highlights the crucial role of lymphatic vessels in skin regeneration. Traditionally associated with fluid dynamics and immune modulation, these vessels are now recognized for interacting with skin stem cells and coordinating regeneration. This Mini Review provides an overview of recent advancements in basic and translational research related to skin regeneration, focusing on the dynamic interplay between lymphatic vessels and skin biology. Key highlights include the critical role of stem cell-lymphatic vessel crosstalk in orchestrating skin regeneration, emerging translational approaches, and their implications for skin diseases. Additionally, the review identifies research gaps and proposes potential future directions, underscoring the significance of this rapidly evolving research arena.
KW - engineered skin
KW - hair follicle
KW - lymphatics
KW - microenvironment
KW - regeneration
KW - skin
KW - skin graft
KW - stem cells
U2 - 10.3389/fphys.2024.1347558
DO - 10.3389/fphys.2024.1347558
M3 - Review
C2 - 38487264
AN - SCOPUS:85187672305
VL - 15
JO - Frontiers in Physiology
JF - Frontiers in Physiology
SN - 1664-042X
M1 - 1347558
ER -
ID: 385899106